CAJ | 학술논문

对1例类风湿因子抗体（RF-IgG）阳性同时伴促甲状腺激素（TSH）升高，按原发性甲减治疗后临床上出现了甲亢症状但血 TSH 仍很高的患者，进行临床和实验分析，以零 TSH 血清等倍稀释，观察其变化曲线。用蛋白质 G 琼脂糖树脂去除血清中 IgG ，并以缓冲液对未过柱等量血清进行同倍稀释，以排除过柱过程中缓冲液对测定的影响，比较过柱前后TSH 水平，发现 TSH 明显降低，证明 RF-IgG 可造成 TSH 假性增高，并证实蛋白质 G 琼脂糖树脂可去除血清中 RF-IgG ，消除该干扰。
대1례류풍습인자항체（RF-IgG）양성동시반촉갑상선격소（TSH）승고，안원발성갑감치료후림상상출현료갑항증상단혈 TSH 잉흔고적환자，진행림상화실험분석，이령 TSH 혈청등배희석，관찰기변화곡선。용단백질 G 경지당수지거제혈청중 IgG ，병이완충액대미과주등량혈청진행동배희석，이배제과주과정중완충액대측정적영향，비교과주전후TSH 수평，발현 TSH 명현강저，증명 RF-IgG 가조성 TSH 가성증고，병증실단백질 G 경지당수지가거제혈청중 RF-IgG ，소제해간우。
A female patient with high serum TSH and extremely high rheumatoid factor (RF)-IgG was treated with thyroid hormone replacement therapy but in vain ,then the reason of high serum TSH in this patient was analyzed .Firstly ,diluted the serum with zero-TSH serum ,the dilution curve was un-linear .Secondly ,used protein G agarose resin was used to remove IgG in the serum ,diluted the serum with buffer in the same ratio ,compared with the serum only diluted with buffer ,the TSH level of the serum treated with protein G decreased .The result was that the high titer of IgG could cause falsely high concentration of TSH ,and the protein G agarose resin could eliminate the interference .