CAJ | 학술논문

目的：采用Allegro Oculyzer眼前节诊断系统探讨飞秒准分子激光原位角膜磨镶术矫正近视术后1年内角膜后表面高度变化规律。方法：选择行飞秒激光LASIK矫正近视（术前等效球镜-10．63～-1．63 D）患者45例（90只眼），采用 Allegro Oculyzer 眼前节诊断系统分别在术前、术后1、3、6个月及1年对术眼进行眼前节三维图像采集，分别测量角膜中央后表面高度、角膜最薄点厚度并计算角膜后表面高度差异。采用重复测量的方差分析和Pearson 相关分析。结果：飞秒激光 LASIK 术前与术后不同随访时间点角膜后表面高度进行重复测量的方差分析示，差异无统计学意义（F＝1．50，P ＞0．05）。飞秒激光 LASIK 术后1、3、6个月及1年角膜后表面高度差异进行重复测量的方差分析，差异无统计学意义（F＝1．47， P＞0．05）。术前及术后不同随访时间点角膜最薄点厚度进行重复测量的方差分析，差异有统计学意义（F ＝369．10，P ＜0．01）。飞秒激光LASIK术后不同随访时间角膜后表面高度与SE、AD、RBT、AP/TCT及“（角膜瓣厚度＋切削厚度）/术前角膜最薄点厚度”，无相关关系（ P ＞0．05）。结论：严格掌握手术适应证的飞秒 LASIK 术后角膜后表面稳定性良好，角膜后表面高度并未发生明显的变化；角膜最薄点厚度逐渐增加并于术后3个月趋于稳定。
목적：채용Allegro Oculyzer안전절진단계통탐토비초준분자격광원위각막마양술교정근시술후1년내각막후표면고도변화규률。방법：선택행비초격광LASIK교정근시（술전등효구경-10．63～-1．63 D）환자45례（90지안），채용 Allegro Oculyzer 안전절진단계통분별재술전、술후1、3、6개월급1년대술안진행안전절삼유도상채집，분별측량각막중앙후표면고도、각막최박점후도병계산각막후표면고도차이。채용중복측량적방차분석화Pearson 상관분석。결과：비초격광 LASIK 술전여술후불동수방시간점각막후표면고도진행중복측량적방차분석시，차이무통계학의의（F＝1．50，P ＞0．05）。비초격광 LASIK 술후1、3、6개월급1년각막후표면고도차이진행중복측량적방차분석，차이무통계학의의（F＝1．47， P＞0．05）。술전급술후불동수방시간점각막최박점후도진행중복측량적방차분석，차이유통계학의의（F ＝369．10，P ＜0．01）。비초격광LASIK술후불동수방시간각막후표면고도여SE、AD、RBT、AP/TCT급“（각막판후도＋절삭후도）/술전각막최박점후도”，무상관관계（ P ＞0．05）。결론：엄격장악수술괄응증적비초 LASIK 술후각막후표면은정성량호，각막후표면고도병미발생명현적변화；각막최박점후도축점증가병우술후3개월추우은정。
Objective To study the changes of posterior corneal elevation with one-year follow-up by using Allegro Oculyzer anterior segment diagnostic system in patients who had undergone laser in situ keratomileusis with femtosecond laser (FS-LASIK) for myopia. Methods Ninety eyes of forty-five patients who had undergone FS-LASIK for myopia were included in our study . The spherical equivalent of ametropia was-10.63D to -1.63D. The preoperative and postoperative corneal tomography (including 1, 3, 6 and 12 month after operation ) were collected by Allegro Oculyzer in the posterior corneal elevation and the thickness at central corneal thinnest point of each eye were measured , and the differences of the posterior corneal elevation were calculated. The data were analyzed with ANOVA and Pearson correlation analysis. Results There were no statistically significant differences in the changes of posterior corneal elevation from the preoperative time to the any postoperative follow-up time (F = 1.50, P > 0.05). There were no statistically significant changes of the posterior corneal elevation from the 1st month to 12th month postoperatively (F = 1.47, P > 0.05). There were statistically significant differences in the changes of thickness at central corneal thinnest point from the preoperative to the 12th month postoperative (F = 369.10, P <0.01). At postoperative time, the posterior corneal elevation was not correlated with several factors including spherical equivalent , ablation depth , residual bed thickness, ablation percentage per total corneal thickness and "(corneal flap thickness + ablation depth) /thinnest point preoperative corneal thickness" (P > 0.05). Conclusion After strictly followed surgical indications in FS-LASIK, the posterior corneal elevation can keep good stability and has no significant change. Thickness of central cornea thinnest point increases gradually and tends to stablity at the 3th months after surgery.