CAJ | 학술논문

利用生物酶高反应活性、高区域及立体选择性和催化反应条件温和等优点，酶催化拆分技术已应用于多种重要的手性化合物单一对映体的制备中。化学合成与酶催化联合，二者优势互补，使得手性化合物的制备原料易得、工艺简捷高效且环境友好，获得的手性单一对映体的光学纯度高，因此化学-酶联合催化技术越来越受到人们的关注，不断地被开发并应用于传统化学法不易制备的手性化合物的合成体系中。本文总结和评述了近年来国内外化学-酶催化技术合成醇类、胺类和氨基酸类以及其他手性化合物的研究进展，并对其发展趋势进行了展望。
이용생물매고반응활성、고구역급입체선택성화최화반응조건온화등우점，매최화탁분기술이응용우다충중요적수성화합물단일대영체적제비중。화학합성여매최화연합，이자우세호보，사득수성화합물적제비원료역득、공예간첩고효차배경우호，획득적수성단일대영체적광학순도고，인차화학-매연합최화기술월래월수도인문적관주，불단지피개발병응용우전통화학법불역제비적수성화합물적합성체계중。본문총결화평술료근년래국내외화학-매최화기술합성순류、알류화안기산류이급기타수성화합물적연구진전，병대기발전추세진행료전망。
Due to high catalytic activity,regio-and stereo-selectivities and the reactions under mild conditions commonly displayed by enzymes,a variety significant single enantiomers of chiral compounds had been obtained by the technology of enzyme catalysis successfully. Coupling chemical synthesis with enzyme catalysis,the chemo-enzymatic synthesis had shown the complementary ad-vantages,such as large resource for raw materials,straightforward and high efficiency,high optical purity of products and environ-ment friendly,which had gained increased attention. The new systems of chemo-enzymatic synthesis were constantly developed and applied to prepare many chiral building blocks which were difficult to prepare efficiently for traditional chemical synthesis. In this paper,the recent development of chemo-enzymatic synthesis had been shown including preparation of the chiral alcohols,chiral a-mine and amino acids,and other chiral compound respectively. And the focus points for the chemo-enzymatic synthesis in the future had also been demonstrated in the end.