CAJ | 학술논문

脑转移瘤瘤周水肿指脑转移肿瘤周围脑实质内水分的异常增多，是影响患者生活质量和治疗疗效的关键因素之一，其发生机制复杂，影响因素众多。可能与血管内皮生长因子及其受体、水通道蛋白-4、金属基质蛋白酶-9、白细胞介素-6、乏氧诱导因子及其他分子生物学因素有关，上述分子生物学因素的深入研究可以为瘤周水肿的防治、监测、治疗及预后提供依据。瘤周水肿的治疗除传统的脱水治疗外，相关分子生物学因素的运用可以为其提供新的途径和方向，其中水通道蛋白-4激动剂或拮抗剂，血管内皮生长因子受体拮抗剂已逐步在临床中得到初步应用。本文就脑转移瘤瘤周水肿相关分子生物学因素进行综述。
뇌전이류류주수종지뇌전이종류주위뇌실질내수분적이상증다，시영향환자생활질량화치료료효적관건인소지일，기발생궤제복잡，영향인소음다。가능여혈관내피생장인자급기수체、수통도단백-4、금속기질단백매-9、백세포개소-6、핍양유도인자급기타분자생물학인소유관，상술분자생물학인소적심입연구가이위류주수종적방치、감측、치료급예후제공의거。류주수종적치료제전통적탈수치료외，상관분자생물학인소적운용가이위기제공신적도경화방향，기중수통도단백-4격동제혹길항제，혈관내피생장인자수체길항제이축보재림상중득도초보응용。본문취뇌전이류류주수종상관분자생물학인소진행종술。
Peritumoral edema (PTE) of the metastasis tumor of brain (MTB) refers to the abnormal increase of moisture in the surrounding cerebral parenchyma of the brain tumor. The mechanism of PTE occurrence of MTB is complicated, and the influencing factors are diverse. PTE is one of the key factors that affect patient survival and cure. Researchers from China and overseas believe that it may be related to the expression of the vascular endothelial growth factor (VEGF) or VEGF receptor, aquaporin-4 (AQP-4), matrix metalloproteinase-9, interleukin-6, hypoxia inducible factor-1a, and other molecular biology factors. Studies of these molecular biologi-cal factors provide objective scientific evidence for the prevention, control, monitoring, treatment, and prognosis of PTE of metasta-sized brain tumor. In addition to the traditional dehydration therapy of PTE, the use of PTE-related molecular biological factors pro-vides a new approach for the treatment. AQP-4 agonists or antagonists and VEGF receptor antagonists also have good therapeutic poten-tials. In this paper, the authors reviewed the PTE-related molecular biological factors of MTB.