CAJ | 학술논문

Lin28是一种结构上高度保守的RNA结合蛋白，其在机体正常生长发育代谢及某些疾病状态，如肿瘤发生发展中有重要作用。近年的研究发现，Lin28在机体中的过表达能够抑制let-7 miRNA的功能，并上调某些细胞周期相关基因如cyclin A、cyclin B等的表达，从而促进干细胞的增殖。在人类恶性肿瘤细胞中，Lin28的激活能选择性地阻断原始let-7 miRNA的加工成熟并最终促进肿瘤的发生；Lin28在肿瘤疾病进程中的其他作用机制包括：通过抑制肿瘤相关microRNA的分化成熟、上调细胞周期相关基因的表达影响肿瘤的发展及预后。另外，Lin28在肿瘤放化疗耐受相关研究中的重要作用日益凸显。为此，本文对Lin28的相关生理功能和其在肿瘤发生发展的相关机制及治疗前景做一综述。
Lin28시일충결구상고도보수적RNA결합단백，기재궤체정상생장발육대사급모사질병상태，여종류발생발전중유중요작용。근년적연구발현，Lin28재궤체중적과표체능구억제let-7 miRNA적공능，병상조모사세포주기상관기인여cyclin A、cyclin B등적표체，종이촉진간세포적증식。재인류악성종류세포중，Lin28적격활능선택성지조단원시let-7 miRNA적가공성숙병최종촉진종류적발생；Lin28재종류질병진정중적기타작용궤제포괄：통과억제종류상관microRNA적분화성숙、상조세포주기상관기인적표체영향종류적발전급예후。령외，Lin28재종류방화료내수상관연구중적중요작용일익철현。위차，본문대Lin28적상관생리공능화기재종류발생발전적상관궤제급치료전경주일종술。
Lin28 is a highly conserved RNA-binding protein that has an important role in human body development, metabolism, and tumorigenesis. Previous studies have found that the activation of Lin28 can suppress the maturity of let-7 miRNA in stem cells and promote the proliferation of stem cells by upregulating cell-cycle related genes, such as cyclins A and B. Other mechanisms underlying the activation of Lin28 can selectively block the processes of pre-let-7 miRNA in embryonic stem cells and ultimately promote tumori-genesis. In addition, Lin28 affects the occurrence, development, and prognosis of cancer by inhibiting the differentiation and maturation of miRNA and by moderating the expression of some cell-cycle related genes. Lin28 has an important function in the tumor's tolerance of chemotherapy and radiotherapy. We review the physiological function of Lin28 in tumors and its function in tumor treatment.