中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
7期
968-969
,共2页
李娜%程晋成%齐一龙%张文娟%孙灵迪%邵先安
李娜%程晉成%齊一龍%張文娟%孫靈迪%邵先安
리나%정진성%제일룡%장문연%손령적%소선안
颅脑损伤%内皮素-1%脑脊髓液%血清
顱腦損傷%內皮素-1%腦脊髓液%血清
로뇌손상%내피소-1%뇌척수액%혈청
Craniocerebral trauma%Endothelin-1%Cerebospinal fluid%Serum
目的：探讨急性颅脑损伤患者脑脊液（ CSF ）和血清内皮素-1（ ET-1）含量及其临床意义。方法36例急性颅脑损伤患者和对照组以GCS评分分组（ GCS≤12分为中／重型颅脑损伤组、GCS＞12分为轻型颅脑损伤组），采用双抗体夹心（ELISA）法对患者CSF和血清ET-1浓度进行检测。结果颅脑损伤中，中／重型颅脑损伤组CSF中ET-1浓度[（38．89±9．50）μg／L]显著高于轻型颅脑损伤组[（22．25±8．55）μg／L]（t＝5．453，P＝0．000）和对照组[（15．67±7．72）μg／L]（t ＝8．347，P＝0．000）；轻型颅脑损伤组 CSF 中ET-1浓度也高于对照组（t＝2．390，P＝0．023）。中／重型颅脑损伤组血清ET-1浓度[（107．02±17．25）μg／L]显著高于轻型颅脑损伤组[（46．21±11．19）μg／L]（t＝12．176，P＝0．000）和对照组[（32．34±10．64）μg／L]（t＝16．163，P＝0.000）；轻型颅脑损伤组血清ET-1浓度也高于对照组（t＝3．751，P＝0．001）。在所有研究对象中，血清ET-1浓度高于脑脊液（t＝9．974，P＝0．000）。结论急性颅脑损伤患者ET-1水平与颅脑损伤的程度有关。
目的：探討急性顱腦損傷患者腦脊液（ CSF ）和血清內皮素-1（ ET-1）含量及其臨床意義。方法36例急性顱腦損傷患者和對照組以GCS評分分組（ GCS≤12分為中／重型顱腦損傷組、GCS＞12分為輕型顱腦損傷組），採用雙抗體夾心（ELISA）法對患者CSF和血清ET-1濃度進行檢測。結果顱腦損傷中，中／重型顱腦損傷組CSF中ET-1濃度[（38．89±9．50）μg／L]顯著高于輕型顱腦損傷組[（22．25±8．55）μg／L]（t＝5．453，P＝0．000）和對照組[（15．67±7．72）μg／L]（t ＝8．347，P＝0．000）；輕型顱腦損傷組 CSF 中ET-1濃度也高于對照組（t＝2．390，P＝0．023）。中／重型顱腦損傷組血清ET-1濃度[（107．02±17．25）μg／L]顯著高于輕型顱腦損傷組[（46．21±11．19）μg／L]（t＝12．176，P＝0．000）和對照組[（32．34±10．64）μg／L]（t＝16．163，P＝0.000）；輕型顱腦損傷組血清ET-1濃度也高于對照組（t＝3．751，P＝0．001）。在所有研究對象中，血清ET-1濃度高于腦脊液（t＝9．974，P＝0．000）。結論急性顱腦損傷患者ET-1水平與顱腦損傷的程度有關。
목적：탐토급성로뇌손상환자뇌척액（ CSF ）화혈청내피소-1（ ET-1）함량급기림상의의。방법36례급성로뇌손상환자화대조조이GCS평분분조（ GCS≤12분위중／중형로뇌손상조、GCS＞12분위경형로뇌손상조），채용쌍항체협심（ELISA）법대환자CSF화혈청ET-1농도진행검측。결과로뇌손상중，중／중형로뇌손상조CSF중ET-1농도[（38．89±9．50）μg／L]현저고우경형로뇌손상조[（22．25±8．55）μg／L]（t＝5．453，P＝0．000）화대조조[（15．67±7．72）μg／L]（t ＝8．347，P＝0．000）；경형로뇌손상조 CSF 중ET-1농도야고우대조조（t＝2．390，P＝0．023）。중／중형로뇌손상조혈청ET-1농도[（107．02±17．25）μg／L]현저고우경형로뇌손상조[（46．21±11．19）μg／L]（t＝12．176，P＝0．000）화대조조[（32．34±10．64）μg／L]（t＝16．163，P＝0.000）；경형로뇌손상조혈청ET-1농도야고우대조조（t＝3．751，P＝0．001）。재소유연구대상중，혈청ET-1농도고우뇌척액（t＝9．974，P＝0．000）。결론급성로뇌손상환자ET-1수평여로뇌손상적정도유관。
Objective To elucidate clinical significance of the varied concentration of cytokines in patients , the concentration of endothelin-1(ET-1) in cerebrospinal fluid(CSF) and serum were investigated in 36 patients with acute craniocerebral injury .Methods In this study ,36 patients with acute craniocerebral injury were divided into two groups by their GCS scores ( GCS≤12 as moderate-severe injury group ,GCS>12 as mild injury group ) .Concentration of ET-1 in CSF and serum in 36 patients with acute craniocerebral injury were detected by ELISA .Results The con-centration of ET-1 was(38.89 ±9.50)μg/L in cerebrospinal fluid ( CSF) in moderate to severe patients ,which were significantly higher than that in mild injury groups [(22.25 ±8.55)μg/L](t=5.453,P=0.000) and control groups [(15.67 ±7.72)μg/L](t=8.347,P=0.000).And the levels of ET-1 in CSF in the mild injury groups were also obviously higher than that of the control groups (t=2.390,P=0.023).On the other hand,the concentration of ET-1 was(107.02 ±17.25)μg/L in sera in moderate to severe patients ,which were also significantly higher than that in mild injury groups[(46.21 ±11.19)μg/L](t=12.176,P=0.000)and control groups[(32.34 ±10.64)μg/L] (t=16.163,P=0.000).And the levels of ET-1 in sera in the mild injury groups were obviously higher than that of the control groups(t=3.751,P=0.001).The concentration of ET-1 in sera was significantly higher than that of CSF (t=9.974,P=0.000).Conclusion The concentration of ET-1 in CSF and sera in patients with acute craniocere-bral injury were associated with severe of brain injury .
