中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
7期
966-967
,共2页
吕燕平%刘炯%潘春香%冯羡菊%喻东%梁珍珍
呂燕平%劉炯%潘春香%馮羨菊%喻東%樑珍珍
려연평%류형%반춘향%풍이국%유동%량진진
铜绿假单胞菌%投药法%肺疾病,慢性阻塞性%美罗培南
銅綠假單胞菌%投藥法%肺疾病,慢性阻塞性%美囉培南
동록가단포균%투약법%폐질병,만성조새성%미라배남
Pseudomonas aeruginosa%Medication%Pulmonary disease,chronic obstructive%Multi-drug
目的：评价美罗培南两步输注法治疗老年人COPD并院内获得性多重耐药铜绿假单胞菌肺炎的疗效。方法选取老年COPD并院内获得性多重耐药铜绿假单胞菌肺炎患者112例，数字表法随机分为两组，各56例，观察组采用两步输注法，第一步，在30 min内把单次剂量中的一半药物快速滴注完；第二步，把单次剂量的剩余一半药物在2．5 h内持续缓慢滴注。对照组采用美罗培南常规30 min滴注法。观察两组患者的临床疗效及细菌学疗效。结果观察组、对照组有效率分别为82．2％（46／56）、57．1％（32／56），差异有统计学意义（χ2＝10．185，P＜0．05）；观察组、对照组细菌清除率分别为75．0％（42／56）、46．4％（26／56），差异有统计学意义（χ2＝10．265，P＜0．05）。结论使用美罗培南两步输注法治疗老年人COPD并院内获得性多重耐药铜绿假单胞菌肺炎的疗效优于传统输注方案。
目的：評價美囉培南兩步輸註法治療老年人COPD併院內穫得性多重耐藥銅綠假單胞菌肺炎的療效。方法選取老年COPD併院內穫得性多重耐藥銅綠假單胞菌肺炎患者112例，數字錶法隨機分為兩組，各56例，觀察組採用兩步輸註法，第一步，在30 min內把單次劑量中的一半藥物快速滴註完；第二步，把單次劑量的剩餘一半藥物在2．5 h內持續緩慢滴註。對照組採用美囉培南常規30 min滴註法。觀察兩組患者的臨床療效及細菌學療效。結果觀察組、對照組有效率分彆為82．2％（46／56）、57．1％（32／56），差異有統計學意義（χ2＝10．185，P＜0．05）；觀察組、對照組細菌清除率分彆為75．0％（42／56）、46．4％（26／56），差異有統計學意義（χ2＝10．265，P＜0．05）。結論使用美囉培南兩步輸註法治療老年人COPD併院內穫得性多重耐藥銅綠假單胞菌肺炎的療效優于傳統輸註方案。
목적：평개미라배남량보수주법치료노년인COPD병원내획득성다중내약동록가단포균폐염적료효。방법선취노년COPD병원내획득성다중내약동록가단포균폐염환자112례，수자표법수궤분위량조，각56례，관찰조채용량보수주법，제일보，재30 min내파단차제량중적일반약물쾌속적주완；제이보，파단차제량적잉여일반약물재2．5 h내지속완만적주。대조조채용미라배남상규30 min적주법。관찰량조환자적림상료효급세균학료효。결과관찰조、대조조유효솔분별위82．2％（46／56）、57．1％（32／56），차이유통계학의의（χ2＝10．185，P＜0．05）；관찰조、대조조세균청제솔분별위75．0％（42／56）、46．4％（26／56），차이유통계학의의（χ2＝10．265，P＜0．05）。결론사용미라배남량보수주법치료노년인COPD병원내획득성다중내약동록가단포균폐염적료효우우전통수주방안。
Objective To evaluate the efficacy of a two-step infusion therapy with meropenem against noso-comial multi-drug resistant Pseudomonas aeruginosa infections in elderly patients with chronic obstructive pulmonary disease.Methods 112 elderly patients with nosocomial multi-drug resistant Pseudomonas aeruginosa infections and chronic obstructive pulmonary disease were randomized into two groups:two-step infusion therapy group ( rapid first-step infusion in 30 minutes and slow second-step infusion in 2.5 hours) and traditional 30 minutes infusion therapy group.The antibiotic clinical efficacy and bacteriological efficacy were observed between two groups .Results The clinical efficacy of observation group and control group were 82.2%(46/56) vs 57.1%(32/56).The difference was statistically significant(χ2 =10.185,P<0.05);The bacteriological efficacy of observation group and control group were 75.0%(42/56) vs 46.4%(26/56),The difference was statistically significant (χ2 =10.265,P<0.05). Conclusion The clinical efficacy and bacteriological efficacy of two-step infusion therapy with meropenem against nosocomial multi-drug resistant Pseudomonas aeruginosa infections in elderly patients with chronic obstructive pulmo -nary disease were superior to the traditional therapy .
