CAJ | 학술논문

目的：探讨老年患者医院下呼吸道感染铜绿假单胞菌（ PAE）耐药特点，为临床合理选用抗菌药物和预防泛耐药菌的发生提供依据。方法回顾性分析和评价2010年5月至2012年6月347例老年患者医院下呼吸道感染PAE药物敏感试验结果。结果347例老年患者医院下呼吸道感染PAE对抗菌药物的耐药较严重，氨苄西林、头孢唑啉耐药率均为100．0％，氨苄西林／舒巴坦、妥布霉素、磺胺甲噁唑／甲氧苄啶耐药率分别为95．1％、86．8％、83．6％。对亚胺培南耐药率已达19．6％，泛耐药菌的检出率为4．9％。结论老年患者医院下呼吸道感染PAE耐药性日趋严重，应根据药物敏感试验结果合理选择抗菌药物，防止泛耐药菌的产生与流行。
목적：탐토노년환자의원하호흡도감염동록가단포균（ PAE）내약특점，위림상합리선용항균약물화예방범내약균적발생제공의거。방법회고성분석화평개2010년5월지2012년6월347례노년환자의원하호흡도감염PAE약물민감시험결과。결과347례노년환자의원하호흡도감염PAE대항균약물적내약교엄중，안변서림、두포서람내약솔균위100．0％，안변서림／서파탄、타포매소、광알갑오서／갑양변정내약솔분별위95．1％、86．8％、83．6％。대아알배남내약솔이체19．6％，범내약균적검출솔위4．9％。결론노년환자의원하호흡도감염PAE내약성일추엄중，응근거약물민감시험결과합리선택항균약물，방지범내약균적산생여류행。
Objective To explore the characterization of antibiotic resistance in hospitalized elderly patients with lower respiratory tract infection caused by Pseudomonas Aeruginosa ,and provide scientific basis for clinical ra-tional use of antimicrobial drugs and prevent the emergence of pan-drug resistant bacteria .Methods The drug sensi-tive tests of 347 hospitalized elderly patients with lower respiratory tract infection caused by Pseudomonas Aeruginosa in Shandong provincial hospital affinited to Shandong university from May 2010 to June 2012 were analyzed retrospec-tively.Results The antimicrobial resistance of the 347 cases was rather serious .The resistant rates of ampicillin and cefazolin were both 100.0%.Followed by ampicillin/sulbactam,tobramycin,sulfamethoxazole/trimethoprim,the re-sistant rates were 95.1%,86.8%and 83.6%respectively.The resistant rate of imipenem has reached 19.6%,and the detection rate of pan-drug bacteria was 4.9%.Conclusion The antibiotic resistance in hospitalized elderly pa-tients with lower respiratory tract infection caused by Pseudomonas Aeruginosa has become more and more serious .In order to prevent the emergence and prevalence of pan-drug resistant bacteria , antibacterial agents should be chosen reasonably according to the results of drug sensitive tests .