中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2014年
8期
522-525
,共4页
肠道%神经内分泌肿瘤%临床病理特点%转移
腸道%神經內分泌腫瘤%臨床病理特點%轉移
장도%신경내분비종류%림상병리특점%전이
intestinal tract%neuroendocrine tumors%clinico-pathological features%metastasis
目的：探讨肠道神经内分泌肿瘤临床病理特点及治疗、生存情况。方法：回顾性分析82例肠道神经内分泌肿瘤的临床及病理资料。结果：全组男女患者比例为1.41：1，平均年龄（48.72±13.26）岁，其中神经内分泌瘤72例，神经内分泌癌7例，混合性腺神经内分泌癌3例。直肠为最常见原发部位，主要临床表现为腹痛、排便异常。全组患者5年生存率为78%，神经内分泌瘤患者5年生存率为80%。不同组织学类型的肠道神经内分泌肿瘤患者原发部位、pT分期、淋巴结和远处转移情况的差异均有统计学意义（均P<0.05）。肠道神经内分泌肿瘤的转移与pT分期、病理学类型、年龄、原发部位有关（均P<0.05）。多因素Logistic回归分析的结果显示，肿瘤发病年龄是发生转移的重要因素。结论：肠道神经内分泌肿瘤多发于男性，直肠最多见。肿瘤的发病年龄是影响肠道神经内分泌肿瘤转移的重要因素。
目的：探討腸道神經內分泌腫瘤臨床病理特點及治療、生存情況。方法：迴顧性分析82例腸道神經內分泌腫瘤的臨床及病理資料。結果：全組男女患者比例為1.41：1，平均年齡（48.72±13.26）歲，其中神經內分泌瘤72例，神經內分泌癌7例，混閤性腺神經內分泌癌3例。直腸為最常見原髮部位，主要臨床錶現為腹痛、排便異常。全組患者5年生存率為78%，神經內分泌瘤患者5年生存率為80%。不同組織學類型的腸道神經內分泌腫瘤患者原髮部位、pT分期、淋巴結和遠處轉移情況的差異均有統計學意義（均P<0.05）。腸道神經內分泌腫瘤的轉移與pT分期、病理學類型、年齡、原髮部位有關（均P<0.05）。多因素Logistic迴歸分析的結果顯示，腫瘤髮病年齡是髮生轉移的重要因素。結論：腸道神經內分泌腫瘤多髮于男性，直腸最多見。腫瘤的髮病年齡是影響腸道神經內分泌腫瘤轉移的重要因素。
목적：탐토장도신경내분비종류림상병리특점급치료、생존정황。방법：회고성분석82례장도신경내분비종류적림상급병리자료。결과：전조남녀환자비례위1.41：1，평균년령（48.72±13.26）세，기중신경내분비류72례，신경내분비암7례，혼합성선신경내분비암3례。직장위최상견원발부위，주요림상표현위복통、배편이상。전조환자5년생존솔위78%，신경내분비류환자5년생존솔위80%。불동조직학류형적장도신경내분비종류환자원발부위、pT분기、림파결화원처전이정황적차이균유통계학의의（균P<0.05）。장도신경내분비종류적전이여pT분기、병이학류형、년령、원발부위유관（균P<0.05）。다인소Logistic회귀분석적결과현시，종류발병년령시발생전이적중요인소。결론：장도신경내분비종류다발우남성，직장최다견。종류적발병년령시영향장도신경내분비종류전이적중요인소。
Objective:To analyze the clinico-pathological features of intestinal neuroendocrine tumors (NET), as well as the treat-ment protocols and survival of intestinal NET patients. Methods:Clinico-pathological features of 82 intestinal NET patients were retro-spectively reviewed. Results:The male to female ratio was 1.41:1 in the group of patients, and the mean age was 48.72 ± 13.26. Up to 72 cases were NET, 7 were neuroendocrine cancer, and 3 were mixed adeno-neuroendocrine carcinoma. The most commonly observed organ exhibiting primary lesion of the tumors was the rectum. The overall five-year survival rates were 78%and 80%among all the pa-tients and among the NET patients, respectively. Tumors of different histological types demonstrated statistically significant differences in terms of primary site, pT stage, and metastasis (P<0.05). The pT stage, histological classification, age, and primary site of the tumors were associated with the metastasis of the intestinal NETs (P<0.05). Age was the main risk factor of metastasis in the tumors. Conclu-sions:Intestinal neuroendocrine neoplasms usually occur in males, and the most commonly involved organ is the rectum. Age is an im-portant factor of neuroendocrine tumor metastasis.
