CAJ | 학술논문

目的：探讨尿α1、β2微球蛋白在2～4期慢性肾病患者中诊断价值。方法解放军总医院2011年12月至2013年5月肾内科的134例住院患者和50例健康体检者的尿α1、β2微球蛋白和其他肾功能指标进行检测分析，采用MDRD公式进行肾小球滤过率计算。结果慢性肾病组尿α1、β2微球蛋白水平明显高于健康对照组，差异有统计学意义（P＜0．01）。2～4期慢性肾病患者中尿α1、β2微球蛋白结果呈明显升高趋势，其差异有统计学意义（P＜0．05）。尿α1、β2微球蛋白在3a和3b期中结果有明显差异，3a期尿α1微球蛋白（20．00±18．9）mg/L、3b期（40．5±28．5）mg/L ；3a期β2微球蛋白（4．1±4．0）mg/L、3b期（10．0±8．7）mg/L。相关分析显示，尿α1、β2微球蛋白与肌酐呈显著正相关，与eGFR呈显著负相关。结论尿α1、β2微球蛋白是用于评价慢性肾脏疾病肾功能较好的实验室指标。
목적：탐토뇨α1、β2미구단백재2～4기만성신병환자중진단개치。방법해방군총의원2011년12월지2013년5월신내과적134례주원환자화50례건강체검자적뇨α1、β2미구단백화기타신공능지표진행검측분석，채용MDRD공식진행신소구려과솔계산。결과만성신병조뇨α1、β2미구단백수평명현고우건강대조조，차이유통계학의의（P＜0．01）。2～4기만성신병환자중뇨α1、β2미구단백결과정명현승고추세，기차이유통계학의의（P＜0．05）。뇨α1、β2미구단백재3a화3b기중결과유명현차이，3a기뇨α1미구단백（20．00±18．9）mg/L、3b기（40．5±28．5）mg/L ；3a기β2미구단백（4．1±4．0）mg/L、3b기（10．0±8．7）mg/L。상관분석현시，뇨α1、β2미구단백여기항정현저정상관，여eGFR정현저부상관。결론뇨α1、β2미구단백시용우평개만성신장질병신공능교호적실험실지표。
Objective To explore the value of urine α1 microglobumin and β2 microglobumin for the diagnosis of stage 2-4 chronic kidney disease (CKD) .Methods Urineα1 microglobumin ,β2 microglobumin and the other indi-cator related to kidney function were analyzed in 134 patients with CKD ( CKD group) and 50 healthy subjects (con-trol group) from December 2011 to May 2013 .The estimated glomerular filtration rate (eGFR) was calculated by u-sing the modified Modification of Diet in Renal Disease (MDRD) equation .Results Levels of urineα1 microglobumin andβ2 microglobumin in CKD group were significantly higher than those in control group (P<0 .01) .Levels of urineα1 microglobumin andβ2 microglobumin were increased with the elevation of disease stages of CKD from stage 2 to stage 4 .Levels of urine α1 microglobumin were (20 .00 ± 18 .9) mg/L in stage 3a and (40 .5 ± 28 .5)mg/L in stage 3b ,and levels of urine β2 microglobumin were (4 .1 ± 4 .0)mg/L in stage 3a and (10 .0 ± 8 .7)mg/L in stage 3b ,the differences between the two groups were significant .Correlation analysis indicated that levels of urine α1 microglobu-min andβ2 microglobumin were positively correlated with to creatinine ,negatively correlated with eGFR .Conclusion Urineα1 microglobumin andβ2 microglobumin might be useful indicators for the assessment of renal damage in pa-tients with CKD .