中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
12期
1957-1962
,共6页
毕鑫%李多玉%杨毅%龚跃昆%李彪
畢鑫%李多玉%楊毅%龔躍昆%李彪
필흠%리다옥%양의%공약곤%리표
生物材料%骨生物材料%人工骨%骨髓间充质干细胞%股骨头坏死%综述
生物材料%骨生物材料%人工骨%骨髓間充質榦細胞%股骨頭壞死%綜述
생물재료%골생물재료%인공골%골수간충질간세포%고골두배사%종술
biocompatible materials%stem cel s%femur head necrosis%review
背景：临床上采用复合骨髓间充质干细胞的人工骨组织材料治疗早期股骨头坏死取得了一定进展。<br> 目的：综述骨髓间充质干细胞的生物学性能及运用其复合不同人工骨组织治疗早期股骨头坏死的研究进展。方法：应用计算机检索2003至2013年PubMed数据库、FMJS数据库，2005至2013年万方数据库、CNKI数据库及 CBM 数据库，检索关键词分别为“bone marrow mesenchymal stem cel s，artificial bone， osteonecrosis of the femoral head；骨髓间充质干细胞，人工骨，股骨头坏死”。<br> 结果与结论：应用骨髓间充质干细胞分别复合天然人工骨、珊瑚人工骨、羟基磷灰石人工骨、钙-磷生物陶瓷人工骨及硫酸钙人工骨等治疗股骨头坏死，可降低坏死股骨头内压力，促进局部毛细血管的修复并改善股骨头血供，促进成骨细胞分化增殖等，最终起到延缓甚至避免人工关节置换治疗。但仍有许多问题有待解决，包括干细胞治疗股骨头坏死病理机制的研究还有待进一步深入；由于个体差异、取材部位、体外培养技术等不同，种子细胞的数量和质量存在明显差异性；目前人工骨组织材料还处于探索研发阶段，运用骨髓间充质干细胞复合人工骨组织材料治疗股骨头坏死缺乏大样本随机对照研究，其远期疗效缺乏随访观察统计，并且适应证的选择及疗效评价标准、手术认知度等缺乏统一量化的标准。
揹景：臨床上採用複閤骨髓間充質榦細胞的人工骨組織材料治療早期股骨頭壞死取得瞭一定進展。<br> 目的：綜述骨髓間充質榦細胞的生物學性能及運用其複閤不同人工骨組織治療早期股骨頭壞死的研究進展。方法：應用計算機檢索2003至2013年PubMed數據庫、FMJS數據庫，2005至2013年萬方數據庫、CNKI數據庫及 CBM 數據庫，檢索關鍵詞分彆為“bone marrow mesenchymal stem cel s，artificial bone， osteonecrosis of the femoral head；骨髓間充質榦細胞，人工骨，股骨頭壞死”。<br> 結果與結論：應用骨髓間充質榦細胞分彆複閤天然人工骨、珊瑚人工骨、羥基燐灰石人工骨、鈣-燐生物陶瓷人工骨及硫痠鈣人工骨等治療股骨頭壞死，可降低壞死股骨頭內壓力，促進跼部毛細血管的脩複併改善股骨頭血供，促進成骨細胞分化增殖等，最終起到延緩甚至避免人工關節置換治療。但仍有許多問題有待解決，包括榦細胞治療股骨頭壞死病理機製的研究還有待進一步深入；由于箇體差異、取材部位、體外培養技術等不同，種子細胞的數量和質量存在明顯差異性；目前人工骨組織材料還處于探索研髮階段，運用骨髓間充質榦細胞複閤人工骨組織材料治療股骨頭壞死缺乏大樣本隨機對照研究，其遠期療效缺乏隨訪觀察統計，併且適應證的選擇及療效評價標準、手術認知度等缺乏統一量化的標準。
배경：림상상채용복합골수간충질간세포적인공골조직재료치료조기고골두배사취득료일정진전。<br> 목적：종술골수간충질간세포적생물학성능급운용기복합불동인공골조직치료조기고골두배사적연구진전。방법：응용계산궤검색2003지2013년PubMed수거고、FMJS수거고，2005지2013년만방수거고、CNKI수거고급 CBM 수거고，검색관건사분별위“bone marrow mesenchymal stem cel s，artificial bone， osteonecrosis of the femoral head；골수간충질간세포，인공골，고골두배사”。<br> 결과여결론：응용골수간충질간세포분별복합천연인공골、산호인공골、간기린회석인공골、개-린생물도자인공골급류산개인공골등치료고골두배사，가강저배사고골두내압력，촉진국부모세혈관적수복병개선고골두혈공，촉진성골세포분화증식등，최종기도연완심지피면인공관절치환치료。단잉유허다문제유대해결，포괄간세포치료고골두배사병리궤제적연구환유대진일보심입；유우개체차이、취재부위、체외배양기술등불동，충자세포적수량화질량존재명현차이성；목전인공골조직재료환처우탐색연발계단，운용골수간충질간세포복합인공골조직재료치료고골두배사결핍대양본수궤대조연구，기원기료효결핍수방관찰통계，병차괄응증적선택급료효평개표준、수술인지도등결핍통일양화적표준。
BACKGROUND:Clinical y, bone marrow mesenchymal stem cel s combined with artificial bones for early osteonecrosis of the femoral head have a wonderful outcome. <br> OBJECTIVE:To review the biological properties of bone marrow mesenchymal stem cel s and to summarize the application progress of bone marrow mesenchymal stem cel s combined with different artificial bones in the treatment of early osteonecrosis of the femoral head. <br> METHODS:PubMed (2003-2013), FMJS (2003-2013), Wanfang (2005-2013), CNKI (2005-2013) and CBM (2005-2013) databases were retrieved by computer using the keywords of“bone marrow mesenchymal stem cel s;artificial bone;osteonecrosis of the femoral head”in Chinese and English. <br> RESULTS AND CONCLUSION:It wil lower the pressure of the femoral head, accelerate repair of the blood capil ary, improve the blood supply, osteoblast proliferation and differentiation, and thus delay or even prevent artificial joint replacement after osteonecrosis of the femoral head by applying bone marrow mesenchymal stem cel s combined with different artificial bones, such as corl ine hydroxyapatite, calcium hydroxylaptite, biological ceramics and calcium sulfate bones. But now, there are stil a lot of problems which need to be solved, including pathological mechanism underlying bone marrow mesenchymal stem cel s for treatment of osteonecrosis of the femoral head, obvious difference between the quantity and quality of seed cel s because of individual difference, different sites and culture techniques. So, artificial bone materials are under review, and large-sample randomized control trials are required. Its long-term outcomes also lack for fol ow-up observation, as wel as there is no a unified quantitative standard for the appropriate selection of indication, curative effect evaluation and the awareness of the operation.
