CAJ | 학술논문

背景：与传统水凝胶相比，智能水凝胶能够对外界刺激诸如温度、pH值、光、磁场等作出不同的应答表现，产生二级结构甚至化学结构的变化，自发组装形成有序的超分子结构，最终形成具有三维结构的凝胶。 　　目的：综述智能水凝胶的研究现状及其在组织工程的应用。 　　方法：应用计算机检索中国知网及PubMed 数据库从建库至2014年有关智能水凝胶在组织工程中应用的文献，检索关键词为“水凝胶，组织工程学，hydrogel，Tissue engineering”。 　　结果与结论：智能水凝胶中包括温度敏感性、pH敏感性、光敏感性、磁敏感性及温度/pH双重敏感性水凝胶，其对于外界环境变化能自动感知并能作出响应性的反应，在药物递送系统、药物释放，修复和改善缺损组织等领域表现出一系列传统材料所没有的突出性能，尤其是在组织工程方面表现出相当的优越性：低免疫原性，减少了炎症和排斥作用；具备生物可降解性；能真正在三维尺度上模拟细胞所处微环境，从而利于细胞黏附、生长、迁移及分化等。
배경：여전통수응효상비，지능수응효능구대외계자격제여온도、pH치、광、자장등작출불동적응답표현，산생이급결구심지화학결구적변화，자발조장형성유서적초분자결구，최종형성구유삼유결구적응효。 　　목적：종술지능수응효적연구현상급기재조직공정적응용。 　　방법：응용계산궤검색중국지망급PubMed 수거고종건고지2014년유관지능수응효재조직공정중응용적문헌，검색관건사위“수응효，조직공정학，hydrogel，Tissue engineering”。 　　결과여결론：지능수응효중포괄온도민감성、pH민감성、광민감성、자민감성급온도/pH쌍중민감성수응효，기대우외계배경변화능자동감지병능작출향응성적반응，재약물체송계통、약물석방，수복화개선결손조직등영역표현출일계열전통재료소몰유적돌출성능，우기시재조직공정방면표현출상당적우월성：저면역원성，감소료염증화배척작용；구비생물가강해성；능진정재삼유척도상모의세포소처미배경，종이리우세포점부、생장、천이급분화등。
BACKGROUND:Compared with traditional hydrogels, intel igent hydrogels can appear to exhibit different responses to different stimuli such as temperature, pH value, light, and magnetic field, produce two-stage structure and alter chemical structure to generate the ordered supramolecular structure by self-assembling, and ultimately cause the formation of the gel with three-dimensional structure. OBJECTIVE:To review the research status of intel igent hydrogels and its application in tissue engineering. METHODS:A computer-based search of CNKI and PubMed databases was performed to retrieve articles addressing intel igent hydrogels in tissue engineering published before 2014. The keywords were“hydrogel, tissue engineering”in Chinese and English. RESULTS AND CONCLUSION:Intel igent hydrogels are classified into temperature sensitivity, pH sensitivity, photosensitivity, magnetic susceptibility and temperature/pH dual responsive hydrogels. The change of the external environment can be automatical y detected and responded. Intel igent hydrogels exhibit a series of outstanding performances in drug delivery systems, drug delivery, repair and improvement of defected tissues, which are not possessed by traditional materials. In particular, the intel igent hydrogels show considerable superiorities in tissue engineering, including low immunogenicity that reducing inflammation and rejection, biodegradability, realizing the three-dimensional scale simulation of cel microenvironment that is conducive to cel adhesion, growth, migration and differentiation.