CAJ | 학술논문

背景：研究认为，三氧化二砷可以抑制血管平滑肌细胞的增殖，促进其凋亡，那么砷对血管平滑肌细胞的增生是否也有同样的抑制作用，砷涂层血管支架能否与血管组织相容，早期较好地被血管内膜覆盖或达到减少内膜过度增生的作用？ 　　目的：观察砷涂层血管支架的血管组织相容性。 　　方法：取大耳白家兔14只，随机分为2组，分别在腹主动脉处植入砷涂层316 L不锈钢支架和316 L不锈钢裸支架，植入28 d后结扎支架部位血管的远端和近端，取下支架部位的血管行苏木精-伊红染色，光镜检查。 　　结果与结论：①大体观察：支架处的血管外径稍大于相邻处血管的外径，呈扩张状态，无肉眼可见的血栓，切开支架，支架表面可见光滑的新生内膜形成，新生内膜表面光滑。②光镜观察：支架丝位于血管的中层，中层平滑肌被压，支架丝周边，血管内膜平滑肌增生，使血管内膜增厚。支架丝的血管腔面可见新生的血管内膜形成并覆盖支架丝，支架丝与血管组织之间可见一薄层黑色物质，为涂层药物砷及其化合物，证明砷涂层支架可以被血管组织覆盖，具有良好的血管组织相容性。
배경：연구인위，삼양화이신가이억제혈관평활기세포적증식，촉진기조망，나요신대혈관평활기세포적증생시부야유동양적억제작용，신도층혈관지가능부여혈관조직상용，조기교호지피혈관내막복개혹체도감소내막과도증생적작용？ 　　목적：관찰신도층혈관지가적혈관조직상용성。 　　방법：취대이백가토14지，수궤분위2조，분별재복주동맥처식입신도층316 L불수강지가화316 L불수강라지가，식입28 d후결찰지가부위혈관적원단화근단，취하지가부위적혈관행소목정-이홍염색，광경검사。 　　결과여결론：①대체관찰：지가처적혈관외경초대우상린처혈관적외경，정확장상태，무육안가견적혈전，절개지가，지가표면가견광활적신생내막형성，신생내막표면광활。②광경관찰：지가사위우혈관적중층，중층평활기피압，지가사주변，혈관내막평활기증생，사혈관내막증후。지가사적혈관강면가견신생적혈관내막형성병복개지가사，지가사여혈관조직지간가견일박층흑색물질，위도층약물신급기화합물，증명신도층지가가이피혈관조직복개，구유량호적혈관조직상용성。
BACKGROUND:Arsenic trioxide is considered to inhibit the proliferation of vascular smooth muscle cel s and promote cel apoptosis. Therefore, we wondered whether the arsenic can inhibit the hyperplasia of vascular smooth muscle cel s, an arsenic-coated stent can be compatible with the vascular tissue, and a better vascular intimal coverage as early as possible can reduce intimal hyperplasia. OBJECTIVE:To observe the vascular histocompatibility of the arsenic-coated stent. METHODS:Fourteen white rabbits were randomized into two groups and respectively subject to the implantation of arsenic-coated 316 L stainless steel stents and bare 316 L stainless steel stents into the abdominal aorta. After 28 days, the distal and proximal parts of the vessel at the implantation site were ligated and the ligated vessel was taken for hematoxylin-eosin staining and light microscope observation. RESULTS AND CONCLUSION:(1) Gross observation:the vessel at the stent site was a little larger than the adjacent vessels in the outer diameter, which was expanded but had no visible thrombus. After cutting the stent, the neointima formed smoothly on the stent surface. (2) Light microscope observation:the stent was located in the middle of the vessel, the medial smooth muscle was pressed, and vascular intimal smooth muscle hyperplasia was found around the stent, thereby thickening the vascular intima. The vascular neointima formed and covered the stent, and there was a thin black layer between the stent and the vascular tissue, which consisted of arsenic and its compounds. These findings suggest that the arsenic-coated stents can be covered with vascular tissues, possessing good vascular histocompatibility.