CAJ | 학술논문

双组份信号转导系统（Two-component signal transduction system ，TCS）广泛存在于原核生物细胞内，对细胞生长、分化、代谢、毒力、持留性、致病性等方面的调控发挥着重要作用。PhoPR TCS作为双组份系统中最基本、最重要的感应外界环境变化，并作出相应反应的调控系统，能够调控结核分枝杆菌（Mycobacterium Tuberculosis ，MTB）更好的适应宿主微环境变化。因此PhoPR TCS作为M TB适应环境变化的重要调控系统已愈来愈受关注，关于PhoPR TCS在M TB的致病机制调控方面的研究正在成为新的热点。
쌍조빈신호전도계통（Two-component signal transduction system ，TCS）엄범존재우원핵생물세포내，대세포생장、분화、대사、독력、지류성、치병성등방면적조공발휘착중요작용。PhoPR TCS작위쌍조빈계통중최기본、최중요적감응외계배경변화，병작출상응반응적조공계통，능구조공결핵분지간균（Mycobacterium Tuberculosis ，MTB）경호적괄응숙주미배경변화。인차PhoPR TCS작위M TB괄응배경변화적중요조공계통이유래유수관주，관우PhoPR TCS재M TB적치병궤제조공방면적연구정재성위신적열점。
Two-component signal transduction system (TCS) exists extensively in prokaryotic cell ,which plays a key role of regulation in the growth ,differentiation ,metabolism ,virulence ,persistence ,and pathogenicity .PhoPR two-component signal transduction system ,as one of two-component systems ,is the most basic and the most importantly sensitive to the envi-ronmental changes and makes corresponding certain reaction system adapt to changes in the host microenvironment .Therefore , PhoPR TCS which is an important regulatory system of Mycobacterium tuberculosis (MTB) to adapt to environmental change has been increasing concern ,even PhoPR TCS is becoming the new front-burner issue in the pathogenesis of M TB regulation of research .