东南国防医药
東南國防醫藥
동남국방의약
JOURNAL OF SOUTHEAST CHINA NATIONAL DEFENCE MEDICAL SCIENCE
2014年
2期
128-131
,共4页
朱皓皞%于晓红%杜丽英%熊敦勇%寇辉%王芳胜
硃皓皞%于曉紅%杜麗英%熊敦勇%寇輝%王芳勝
주호호%우효홍%두려영%웅돈용%구휘%왕방성
宫颈癌%激活蛋白1%免疫组化%病理学
宮頸癌%激活蛋白1%免疫組化%病理學
궁경암%격활단백1%면역조화%병이학
cervical carcinoma%activator protein-1%immunohistochemistry%pathology
目的:探讨激活蛋白1(AP-1)信号通路的重要组分c-jun和c-fos在宫颈癌中的表达及临床意义。方法免疫组织化学( SP)法检测c-jun和c-fos在70例宫颈鳞状细胞癌、30例宫颈上皮内瘤变及20例慢性宫颈炎中的表达情况,同时分析其与宫颈癌临床病理特征和预后的关系。结果70例宫颈癌中c-jun和c-fos的阳性表达率分别为57.1%(40/70)、60.0%(42/70),在30例宫颈上皮内瘤变的表达阳性率分别为53.3%(16/30)、63.3%(19/30),而在20例慢性宫颈炎的表达阳性率均为0;宫颈癌组与宫颈炎组相比差异有统计学意义(P<0.01),宫颈癌组与宫颈上皮瘤病变组相比差异无统计学意义(P>0.05)。 c-jun和c-fos表达与宫颈癌的临床分期、组织学分级、淋巴结转移等分组中差异具有统计学意义(P<0.05),但与患者年龄及肿瘤的大小等分组中的表达差异无统计学意义(P>0.05)。 c-jun和c-fos在宫颈癌的表达呈正相关(r=0.67,P<0.05)。结论 AP-1信号通路活化可能与宫颈鳞状细胞癌发生发展相关,c-jun和c-fos在致瘤过程中可能起协同作用。
目的:探討激活蛋白1(AP-1)信號通路的重要組分c-jun和c-fos在宮頸癌中的錶達及臨床意義。方法免疫組織化學( SP)法檢測c-jun和c-fos在70例宮頸鱗狀細胞癌、30例宮頸上皮內瘤變及20例慢性宮頸炎中的錶達情況,同時分析其與宮頸癌臨床病理特徵和預後的關繫。結果70例宮頸癌中c-jun和c-fos的暘性錶達率分彆為57.1%(40/70)、60.0%(42/70),在30例宮頸上皮內瘤變的錶達暘性率分彆為53.3%(16/30)、63.3%(19/30),而在20例慢性宮頸炎的錶達暘性率均為0;宮頸癌組與宮頸炎組相比差異有統計學意義(P<0.01),宮頸癌組與宮頸上皮瘤病變組相比差異無統計學意義(P>0.05)。 c-jun和c-fos錶達與宮頸癌的臨床分期、組織學分級、淋巴結轉移等分組中差異具有統計學意義(P<0.05),但與患者年齡及腫瘤的大小等分組中的錶達差異無統計學意義(P>0.05)。 c-jun和c-fos在宮頸癌的錶達呈正相關(r=0.67,P<0.05)。結論 AP-1信號通路活化可能與宮頸鱗狀細胞癌髮生髮展相關,c-jun和c-fos在緻瘤過程中可能起協同作用。
목적:탐토격활단백1(AP-1)신호통로적중요조분c-jun화c-fos재궁경암중적표체급림상의의。방법면역조직화학( SP)법검측c-jun화c-fos재70례궁경린상세포암、30례궁경상피내류변급20례만성궁경염중적표체정황,동시분석기여궁경암림상병리특정화예후적관계。결과70례궁경암중c-jun화c-fos적양성표체솔분별위57.1%(40/70)、60.0%(42/70),재30례궁경상피내류변적표체양성솔분별위53.3%(16/30)、63.3%(19/30),이재20례만성궁경염적표체양성솔균위0;궁경암조여궁경염조상비차이유통계학의의(P<0.01),궁경암조여궁경상피류병변조상비차이무통계학의의(P>0.05)。 c-jun화c-fos표체여궁경암적림상분기、조직학분급、림파결전이등분조중차이구유통계학의의(P<0.05),단여환자년령급종류적대소등분조중적표체차이무통계학의의(P>0.05)。 c-jun화c-fos재궁경암적표체정정상관(r=0.67,P<0.05)。결론 AP-1신호통로활화가능여궁경린상세포암발생발전상관,c-jun화c-fos재치류과정중가능기협동작용。
Objective To investigate the expression and clinical significance of activator protein-1 (AP-1),an important sig-naling pathway component of c-jun and c-fos,in cervical cancer .Methods Immunohistochemical ( SP) method was used to detect the expression of c-jun and c-fos in 70 cases of cervical squamous cell carcinoma ,30 cases of cervical intraepithelial lesions and 20 cases of chronic cervicitis .The relationship between expressions and clinicopathologic characteristics and prognostic significance was analyzed . Results The positive expression rates of c-jun and c-fos were 57.1%(40/70) and 60%(42/70) in 70 cases of cervical squamous cell carcinoma.The positive expression rates were 53.3%(16/30) and 63.3%(19/30) in 30 cases of cervical intraepithelial neopla-sia.The positive expression rate in the 20 cases of chronic cervicitis was 0.The expression rate in cervical cancer group and the chronic cervicitis group has a significant difference (P<0.01),in cervical cancer and cervical intraepithelial neoplasia group has not statisti -cally significant difference (P>0.05).The different expression of c-jun and c-fos protein in cervical carcinomas was statistically signif-icant in the different groups of clinical stage ,pathology grading and lymph node metastasis (P<0.05),but was not statistically signifi-cant in the different groups of tumor size and the patient age (P>0.05).Additionally,the expression of c-jun was positively correlated with that of c-fos (r=0.67,P<0.05).Conclusion AP-1 pathway alterations may play a critical role in the development of cervical cancer,and c-jun and c-fos make synergistic action during the process of cervical cancer .