CAJ | 학술논문

目的：研究钾离子通道蛋白 HERG1、Kv3．4在口腔扁平苔藓（oral lichen planus，OLP）中的表达及意义。方法：采用免疫组织化学 SP 技术检测20例 OLP 和16例正常口腔黏膜（normal oral mucosa，NOM）组织中 HERG1及 Kv3．4的表达。结果：HERG1和 Kv3．4在 NOM、非糜烂型 OLP 组织表达阴性或基底层有少量表达；在糜烂型 OLP 基底层、棘细胞层及颗粒层呈阳性表达；HERG1、Kv3．4在 OLP 组织的表达均高于正常组织（P ＜0．05），且糜烂型 OLP 中的表达高于非糜烂型 OLP（P ＜0．05）；在 OLP 中 HERG1与 Kv3．4的表达呈正相关（P ＜0．05）。结论：HERG1、Kv3．4可能与 OLP 的发生发展有关。
목적：연구갑리자통도단백 HERG1、Kv3．4재구강편평태선（oral lichen planus，OLP）중적표체급의의。방법：채용면역조직화학 SP 기술검측20례 OLP 화16례정상구강점막（normal oral mucosa，NOM）조직중 HERG1급 Kv3．4적표체。결과：HERG1화 Kv3．4재 NOM、비미란형 OLP 조직표체음성혹기저층유소량표체；재미란형 OLP 기저층、극세포층급과립층정양성표체；HERG1、Kv3．4재 OLP 조직적표체균고우정상조직（P ＜0．05），차미란형 OLP 중적표체고우비미란형 OLP（P ＜0．05）；재 OLP 중 HERG1여 Kv3．4적표체정정상관（P ＜0．05）。결론：HERG1、Kv3．4가능여 OLP 적발생발전유관。
Objective:To investigate the expression of HERG1 and Kv3.4 in normal oral mucosa(NOM)and oral lichen planus (OLP).Methods:20 OLP and 1 6 NOM specimens were collected and immunohistochemically stained(IHC)by SP method for the detection of HERG1 and Kv3.4 protein expression.Results:HERG1 and Kv3.4 were negative or weak-positive in the sapmles of bas-al layer of NOMand non-erosive OLP,but positive in basal layer,spinous layer and granular layer of erosive OLP.The expression of HERG1 and Kv3.4 was higher in OLP than in NOM tissues (P <0.05);and higher in erosive OLP than in non-erosive OLP(P <0.05).In OLP HERG1 expression was positively related to Kv3.4(P <0.05).Conclusion:HERG1 and Kv3.4 may be related to the development of OLP.