黑龙江医药
黑龍江醫藥
흑룡강의약
HEILONGJIANG MEDICAL JOURNAL
2014年
2期
272-274,275
,共4页
骨关节炎%软骨细胞%生长因子%MMP13
骨關節炎%軟骨細胞%生長因子%MMP13
골관절염%연골세포%생장인자%MMP13
osteoarthritis%articular cartilage%growth factors%Mmp13
骨性关节炎（OA）是一种非常普遍的疾病，可分为原发性和继发性。继发性OA有明确的致病原因，如创伤、炎性关节病、先天性或发育性骨关节病、代谢性或内分泌性疾病等；原发性OA病因及发病机制尚不十分明确，可能与年龄增长、过度使用、损伤、肥胖、遗传等多种因素密切相关。然而，OA分子作用机制是复杂的，目前尚没有有效的治疗。
骨性關節炎（OA）是一種非常普遍的疾病，可分為原髮性和繼髮性。繼髮性OA有明確的緻病原因，如創傷、炎性關節病、先天性或髮育性骨關節病、代謝性或內分泌性疾病等；原髮性OA病因及髮病機製尚不十分明確，可能與年齡增長、過度使用、損傷、肥胖、遺傳等多種因素密切相關。然而，OA分子作用機製是複雜的，目前尚沒有有效的治療。
골성관절염（OA）시일충비상보편적질병，가분위원발성화계발성。계발성OA유명학적치병원인，여창상、염성관절병、선천성혹발육성골관절병、대사성혹내분비성질병등；원발성OA병인급발병궤제상불십분명학，가능여년령증장、과도사용、손상、비반、유전등다충인소밀절상관。연이，OA분자작용궤제시복잡적，목전상몰유유효적치료。
Osteoarthritis (OA) is a very common disease, can be divided into primary and secondary.Secondary OA with clear causes, such as trauma, inflammatory joint disease, congenital or developmental osteoarthropathy, metabolic or internal secretory dis-ease, etc;Primary OA etiology and pathogenesis is not very clear, may be related to age, excessive use, damage, obesity, genetic and other factors are closely related. However, the Molecular mechanisms of this disease are complex, and there is currently no effective disease-modifying treatment. The initiation and progression of OA subtypes is a complex process that at the molecular level probably involves many cell types, signaling pathways, and changes in extracellular rmatrix. This review focuses on molecular mechanisms of OA development related to recent findings.
