黑龙江医药
黑龍江醫藥
흑룡강의약
HEILONGJIANG MEDICAL JOURNAL
2014年
2期
230-231
,共2页
气相色谱法%葡萄糖酸钠%残留溶剂
氣相色譜法%葡萄糖痠鈉%殘留溶劑
기상색보법%포도당산납%잔류용제
Sodium Gluconate%Residual solvent%GC
目的：建立葡萄糖酸钠原料药残留溶剂的测定方法。方法：采用DB-624毛细管色谱柱（30m×0.32mm）、顶空进样法，以FID检测。结果：乙醇、丙酮均在1～200μg·mL-1范围内线性关系良好，平均回收率分别为97.8%、96.1%，RSD分别为2.0％、1.7％。结论：所建立方法专属性好，简便准确，可用于葡萄糖酸钠原料药残留溶剂的限度检查。
目的：建立葡萄糖痠鈉原料藥殘留溶劑的測定方法。方法：採用DB-624毛細管色譜柱（30m×0.32mm）、頂空進樣法，以FID檢測。結果：乙醇、丙酮均在1～200μg·mL-1範圍內線性關繫良好，平均迴收率分彆為97.8%、96.1%，RSD分彆為2.0％、1.7％。結論：所建立方法專屬性好，簡便準確，可用于葡萄糖痠鈉原料藥殘留溶劑的限度檢查。
목적：건립포도당산납원료약잔류용제적측정방법。방법：채용DB-624모세관색보주（30m×0.32mm）、정공진양법，이FID검측。결과：을순、병동균재1～200μg·mL-1범위내선성관계량호，평균회수솔분별위97.8%、96.1%，RSD분별위2.0％、1.7％。결론：소건립방법전속성호，간편준학，가용우포도당산납원료약잔류용제적한도검사。
Objective:To establish a method for determining the residual solvents in Sodium Gluconate by gas chromatography. Methods:The analytical column was DB-624 capillary column( 30m × 0.32mm) . The detector was FID. The injector temperature was 200℃,and the detector temperature was 250℃.The column temperature was 80℃. The injectionsplit ratio was 10∶1. The carrier gas was nitrogen. The column flow was 2.0ml/min. Results: It appeared a goodlinearity in the experimental concentration ( r = 0. 9991~0. 9999) ,The average recovery was 98. 0%~101. 2%. Conclusion:This method is simple and accurate,which can be used to detect the residual solvents in Sodium Gluconate.
