CAJ | 학술논문

【目的】探讨促红细胞生成素（EPO ）对颅内动脉瘤术后脑缺血的影响。【方法】选择行开颅动脉瘤夹闭术且术后发现脑缺血的患者100例，根据患者意愿分为对照组和治疗组，每组50例。治疗组在常规治疗基础上给予EPO皮下注射，对照组常规治疗基础上给予等剂量生理盐水。两组在入院当天及治疗后7 d、14 d、21 d、28 d、35 d均采用美国国立卫生研究院卒中量表（NIHSS）评分，采用MRI的弥散加权成像功能（DWI）测定发现缺血时及缺血后7 d、14 d、21 d、28 d、35 d时脑缺血情况并计算其面积。【结果】治疗组d21、d28、d35 NIHSS评分分别为（8．7±1．8）分、（8．0±1．6）分、（7．0±1．6）分，与对照组相比显著降低（P ＜0．05）；治疗组脑缺血面积缩小百分率在同时间点较对照组显著增加（ P ＜0．05）。【结论】EPO能通过促进缺血脑组织微循环重建的机制保护神经。
【목적】탐토촉홍세포생성소（EPO ）대로내동맥류술후뇌결혈적영향。【방법】선택행개로동맥류협폐술차술후발현뇌결혈적환자100례，근거환자의원분위대조조화치료조，매조50례。치료조재상규치료기출상급여EPO피하주사，대조조상규치료기출상급여등제량생리염수。량조재입원당천급치료후7 d、14 d、21 d、28 d、35 d균채용미국국립위생연구원졸중량표（NIHSS）평분，채용MRI적미산가권성상공능（DWI）측정발현결혈시급결혈후7 d、14 d、21 d、28 d、35 d시뇌결혈정황병계산기면적。【결과】치료조d21、d28、d35 NIHSS평분분별위（8．7±1．8）분、（8．0±1．6）분、（7．0±1．6）분，여대조조상비현저강저（P ＜0．05）；치료조뇌결혈면적축소백분솔재동시간점교대조조현저증가（ P ＜0．05）。【결론】EPO능통과촉진결혈뇌조직미순배중건적궤제보호신경。
[Objective] To explore the impact of erythropoietin(EPO) on cerebral ischemia of patients after in-tracranial aneurysm surgery .[Methods] Totally 100 patients with cerebral ischemia after operation of intracranial aneurysm were chosen .According to patients'will ,all patients were randomly divided into control group and treat-ment group with 50 patients in each group .The treatment group was given subcutaneous injection of EPO based on the routine treatment .The control group was given isovolume normal saline based on the routine treatment .Na-tional institute of health stroke scale (NIHSS) was used on the admission day ,7d ,14d ,21d ,28d and 35d after EPO treatment .Diffusion-weighted imaging (DWI) of MRI was used to determine cerebral ischemia at ischemic day and 7d ,14d ,21d ,28d and 35d after ischemia .The ischemia area was calculated .[Results]Compared with control group ,NIHSS scores of the treatment group at d21 ,d28 and d35 were (8 .7 ± 1 .8) ,(8 .0 ± 1 .6) and (7 .0 ± 1 .6) respectively ,and decreased significantly ( P<0 .05) .Compared with control group ,the percentage of de-creased cerebral ischemia area in treatment group was increased significantly ( P <0 .05) .[Conclusion] EPO can protect the nerve through promoting the reconstruction of microcirculation of ischemic brain tissue .