黑龙江医药
黑龍江醫藥
흑룡강의약
HEILONGJIANG MEDICAL JOURNAL
2014年
2期
224-225,226
,共3页
氯诺昔康%高效液相色谱法%有关物质%2-氨基吡啶
氯諾昔康%高效液相色譜法%有關物質%2-氨基吡啶
록낙석강%고효액상색보법%유관물질%2-안기필정
Lornoxicam%HPLC%related substances%2-aminopyridine
目的:建立高效液相色谱法检查氯诺昔康的有关物质及有害物质2-氨基吡啶。方法:采用十八烷基键合硅胶色谱柱,以0.025mol·L-1磷酸二氢铵溶液(三乙胺调pH值至7.3)-甲醇(58:42)为流动相,流速为1.0ml·min-1,检测波长为290nm,柱温:30℃。结果:2-氨基吡啶、氯诺昔康主峰及各有关物质能够达到有效分离,方法耐用性良好,氯诺昔康检测限为2.006ng,2-氨基吡啶检测限为0.5045ng、定量限为1.009ng,2-氨基吡啶浓度在0.1009μg·mL-1~1.009μg·mL-1范围内线性关系良好(r=0.9997),2-氨基吡啶的平均回收率为106.5%(RSD=3.2%)。结论:本方法简便、稳定、专属性强,可用氯诺昔康有关物质及2-氨基吡啶的检查。
目的:建立高效液相色譜法檢查氯諾昔康的有關物質及有害物質2-氨基吡啶。方法:採用十八烷基鍵閤硅膠色譜柱,以0.025mol·L-1燐痠二氫銨溶液(三乙胺調pH值至7.3)-甲醇(58:42)為流動相,流速為1.0ml·min-1,檢測波長為290nm,柱溫:30℃。結果:2-氨基吡啶、氯諾昔康主峰及各有關物質能夠達到有效分離,方法耐用性良好,氯諾昔康檢測限為2.006ng,2-氨基吡啶檢測限為0.5045ng、定量限為1.009ng,2-氨基吡啶濃度在0.1009μg·mL-1~1.009μg·mL-1範圍內線性關繫良好(r=0.9997),2-氨基吡啶的平均迴收率為106.5%(RSD=3.2%)。結論:本方法簡便、穩定、專屬性彊,可用氯諾昔康有關物質及2-氨基吡啶的檢查。
목적:건립고효액상색보법검사록낙석강적유관물질급유해물질2-안기필정。방법:채용십팔완기건합규효색보주,이0.025mol·L-1린산이경안용액(삼을알조pH치지7.3)-갑순(58:42)위류동상,류속위1.0ml·min-1,검측파장위290nm,주온:30℃。결과:2-안기필정、록낙석강주봉급각유관물질능구체도유효분리,방법내용성량호,록낙석강검측한위2.006ng,2-안기필정검측한위0.5045ng、정량한위1.009ng,2-안기필정농도재0.1009μg·mL-1~1.009μg·mL-1범위내선성관계량호(r=0.9997),2-안기필정적평균회수솔위106.5%(RSD=3.2%)。결론:본방법간편、은정、전속성강,가용록낙석강유관물질급2-안기필정적검사。
Objective:To establish an HPLC method to check lornoxicam related substances and hazardous material 2-aminopyr-idine. Methods:The C18 column was adopted with the mobile phase of 0.025 mol·L-1 ammonium dihydrogen phosphate solution-methanol (58:42) (triethylamine adjusted to pH 7.3) at the flow rate of 1.0 ml·min-1, and the detection wavelength was 290nm, column temperature:30℃. Results:2-aminopyridine, lornoxicam and relevant materials to achieve an effective separation method durability was good. The LOD of lornoxicam was 2.006ng, The LOD of 2-aminopyridine was 0.5045ng, The LOQ of 2-aminopyridine was 1.009 ng. The linear ranges of 2-aminopyridine was 0.100μg·mL-1~1.009μg·mL-1 (r=0.9997). The average recovery of 2-amino-pyridine was 106.5%(RSD=3.2%). Conclusion:The method was simple, stable, specific, and could be used lornoxicam related sub-stances, and 2-aminopyridine checks.