CAJ | 학술논문

【目的】探讨盐酸纳洛酮治疗急性颅脑损伤患者的临床疗效。【方法】选择本院2013年1月至2013年10月收治的50例急性颅脑损伤患者的临床资料，其中，观察组25例患者采用盐酸纳洛酮进行治疗，而对照组25例患者采用常规治疗措施，比较两组患者的临床疗效。【结果】治疗后，观察组患者的总有效率为92．00％，明显高于对照组患者，组间差异具有明显统计学意义（ P ＜0．05），治疗15 d后，观察组患者的颅内压较对照组明显下降，组间差异具有明显统计学意义（ P＜0．05），治疗6 d、8 d、11 d、15 d后，观察组患者的GCS评分均较对照组明显改善，组间差异均具有明显统计学意义（ P ＜0．05）。【结论】早期应用纳洛酮治疗急性颅脑损伤患者具有十分显著的效果，大大降低了伤残率和病死率，有利于患者的预后恢复，值得临床应用。
【목적】탐토염산납락동치료급성로뇌손상환자적림상료효。【방법】선택본원2013년1월지2013년10월수치적50례급성로뇌손상환자적림상자료，기중，관찰조25례환자채용염산납락동진행치료，이대조조25례환자채용상규치료조시，비교량조환자적림상료효。【결과】치료후，관찰조환자적총유효솔위92．00％，명현고우대조조환자，조간차이구유명현통계학의의（ P ＜0．05），치료15 d후，관찰조환자적로내압교대조조명현하강，조간차이구유명현통계학의의（ P＜0．05），치료6 d、8 d、11 d、15 d후，관찰조환자적GCS평분균교대조조명현개선，조간차이균구유명현통계학의의（ P ＜0．05）。【결론】조기응용납락동치료급성로뇌손상환자구유십분현저적효과，대대강저료상잔솔화병사솔，유리우환자적예후회복，치득림상응용。
[Objective] To explore the clinical efficacy of naloxone hydrochloride for the treatment of pa-tients with acute brain injury .[Methods] Clinical data of 50 patients with acute brain injury in our hospital from Jan .2013 to Oct .2013 were collected .The observation group( n=25) was treated with naloxone hydro-chloride ,while the control group( n=25) was treated with conventional treatment .Clinical efficacy was com-pared between two groups .[Results]After treatment ,the total effective rate in the observation group was 92 . 00% which was obviously higher than that in the control group ,and there was significant difference between two groups( P<0 .05) .Compared with the control group ,intracranial pressure in the observation group 15d after treatment was obviously decreased ,and there was significant difference between two groups ( P<0 .05) . Compared with the control group ,GCS score in the observation group 6d ,8d ,11d and 15d after treatment was improved obviously ,and there was significant difference between two groups ( P<0 .05) .[Conclusion] Early use of naloxone for the treatment of patients with acute brain injury has a very significant efficacy ,and greatly reduces the disability and mortality ,and is helpful to restore the prognosis of patients .Therefore it is worthy of clinical application .