神经损伤与功能重建
神經損傷與功能重建
신경손상여공능중건
NEURAL INJURY AND FUNCTIONAL RECONSTRUCTION
2014年
2期
108-110
,共3页
异甘草素%创伤性脑损伤%细胞因子
異甘草素%創傷性腦損傷%細胞因子
이감초소%창상성뇌손상%세포인자
isoliquiritigenin%traumatic brain injury%cytokine
目的：观察异甘草素对创伤性脑损伤大鼠血清干扰素γ（IFNγ）、单核细胞趋化蛋白-1（MCP-1）、白介素-2（IL-2）、IL-4和IL-13的影响。方法：将45只大鼠随机分为假手术组、模型组、治疗组各15只，改良Feeney法建立大鼠脑外伤模型，假手术组仅开骨窗不打击。术后治疗组给予异甘草素治疗，假手术组和模型组给予等量生理盐水，均治疗5d。检测血清中的细胞因子，测量脑含水量，观察海马细胞形态。结果：与模型组相比，治疗组MCP-1、IL-2、IL-4和IL-13含量升高（<0.05），IFNγ含量降低（<0.05），脑含水量减低（<0.05），损伤侧海马组织病理学明显改善。结论：异甘草素可促进创伤性脑损伤大鼠的恢复，其机制可能与调节细胞因子有关。
目的：觀察異甘草素對創傷性腦損傷大鼠血清榦擾素γ（IFNγ）、單覈細胞趨化蛋白-1（MCP-1）、白介素-2（IL-2）、IL-4和IL-13的影響。方法：將45隻大鼠隨機分為假手術組、模型組、治療組各15隻，改良Feeney法建立大鼠腦外傷模型，假手術組僅開骨窗不打擊。術後治療組給予異甘草素治療，假手術組和模型組給予等量生理鹽水，均治療5d。檢測血清中的細胞因子，測量腦含水量，觀察海馬細胞形態。結果：與模型組相比，治療組MCP-1、IL-2、IL-4和IL-13含量升高（<0.05），IFNγ含量降低（<0.05），腦含水量減低（<0.05），損傷側海馬組織病理學明顯改善。結論：異甘草素可促進創傷性腦損傷大鼠的恢複，其機製可能與調節細胞因子有關。
목적：관찰이감초소대창상성뇌손상대서혈청간우소γ（IFNγ）、단핵세포추화단백-1（MCP-1）、백개소-2（IL-2）、IL-4화IL-13적영향。방법：장45지대서수궤분위가수술조、모형조、치료조각15지，개량Feeney법건립대서뇌외상모형，가수술조부개골창불타격。술후치료조급여이감초소치료，가수술조화모형조급여등량생리염수，균치료5d。검측혈청중적세포인자，측량뇌함수량，관찰해마세포형태。결과：여모형조상비，치료조MCP-1、IL-2、IL-4화IL-13함량승고（<0.05），IFNγ함량강저（<0.05），뇌함수량감저（<0.05），손상측해마조직병이학명현개선。결론：이감초소가촉진창상성뇌손상대서적회복，기궤제가능여조절세포인자유관。
ObjectiveTo observe the effects of isoliquiritigenin on levels of serum IFNγ, MCP-1, IL-2, IL-4 and IL-13 in rats after traumatic brain injury (TBI). Methods: Forty-five rats were randomly divided into sham-operated, model and treatment groups with 15 rats in each group. The TBI model was established with the modi-fied Feeney's method. In the rats in the sham-operated group the skull was just window-opened but without any blow. After the operation, the animals in treatment group were given isoliquiritigenin, while the rats in the sham-operated and model groups were given the same volume of normal saline. On day 5 after TBI, the serum cytokines were measured and brain water content was determined. The morphology of neurons in hippocampus was observed. Results:When compared with the model group, the level of IFNγ in the treatment group was de-creased ( <0.05), while the levels of MCP-1,IL-2,IL-4 and IL-13 in the treatment group were increased ( <0.05). The water content of brain in the treatment group was decreased compared to that in the model group( <0.05). And compared with the model group, the morphology of hippocampus was improved ( <0.05).Conclu-sion:Isoliquiritigenin can promote brain tissue rehabilitation in rats after TBI, perhaps mediated by modulation of cytokines.
