中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
14期
2128-2129,2130
,共3页
肺疾病,慢性阻塞性%细菌定植%痰培养
肺疾病,慢性阻塞性%細菌定植%痰培養
폐질병,만성조새성%세균정식%담배양
Pulmonary disease,chronic obstructive%Colonization%Sputum culture
目的：对稳定期慢性阻塞性肺疾病（ SCOPD）患者行痰定量细菌培养及痰细胞分类计数，以探讨下呼吸道细菌定植（ LABC）与气道炎症的相关性。方法选择SCOPD患者47例，通过痰诱导留取痰液，行痰定量细菌培养和痰细胞分类计数，并测定痰液及血清 IL-8水平。结果下呼吸道细菌定植量高于107 CFU/mL的患者共有13例。细菌定植量高于107 CFU/mL的患者血清IL-8（70．65±19．89） pg/mL，痰液IL-8（364．65±74．19）pg/mL。显著高于细菌定植量低于107CFU/mL者的（15．87±3．01）pg/mL和（146．65±28.11）pg/mL，差异均有统计学意义（t＝13．43、9．76，均P＜0．05）。随访1年，细菌载量≥107 CFU/mL者， FEV1下降（0．071±0．016）L，显著高于细菌定植量低于107 CFU/mL者，急性加重次数为（2．93±1．07）次，显著多于细菌定植量低于107 CFU/mL者，其差异均具有统计学意义（t＝5．43、6．54，均P＜0．05）。结论下呼吸道细菌定植可加重SCOPD患者的炎性反应，加重气流受限程度。
目的：對穩定期慢性阻塞性肺疾病（ SCOPD）患者行痰定量細菌培養及痰細胞分類計數，以探討下呼吸道細菌定植（ LABC）與氣道炎癥的相關性。方法選擇SCOPD患者47例，通過痰誘導留取痰液，行痰定量細菌培養和痰細胞分類計數，併測定痰液及血清 IL-8水平。結果下呼吸道細菌定植量高于107 CFU/mL的患者共有13例。細菌定植量高于107 CFU/mL的患者血清IL-8（70．65±19．89） pg/mL，痰液IL-8（364．65±74．19）pg/mL。顯著高于細菌定植量低于107CFU/mL者的（15．87±3．01）pg/mL和（146．65±28.11）pg/mL，差異均有統計學意義（t＝13．43、9．76，均P＜0．05）。隨訪1年，細菌載量≥107 CFU/mL者， FEV1下降（0．071±0．016）L，顯著高于細菌定植量低于107 CFU/mL者，急性加重次數為（2．93±1．07）次，顯著多于細菌定植量低于107 CFU/mL者，其差異均具有統計學意義（t＝5．43、6．54，均P＜0．05）。結論下呼吸道細菌定植可加重SCOPD患者的炎性反應，加重氣流受限程度。
목적：대은정기만성조새성폐질병（ SCOPD）환자행담정량세균배양급담세포분류계수，이탐토하호흡도세균정식（ LABC）여기도염증적상관성。방법선택SCOPD환자47례，통과담유도류취담액，행담정량세균배양화담세포분류계수，병측정담액급혈청 IL-8수평。결과하호흡도세균정식량고우107 CFU/mL적환자공유13례。세균정식량고우107 CFU/mL적환자혈청IL-8（70．65±19．89） pg/mL，담액IL-8（364．65±74．19）pg/mL。현저고우세균정식량저우107CFU/mL자적（15．87±3．01）pg/mL화（146．65±28.11）pg/mL，차이균유통계학의의（t＝13．43、9．76，균P＜0．05）。수방1년，세균재량≥107 CFU/mL자， FEV1하강（0．071±0．016）L，현저고우세균정식량저우107 CFU/mL자，급성가중차수위（2．93±1．07）차，현저다우세균정식량저우107 CFU/mL자，기차이균구유통계학의의（t＝5．43、6．54，균P＜0．05）。결론하호흡도세균정식가가중SCOPD환자적염성반응，가중기류수한정도。
Objective To detect sputum quantitative bacterial culture and sputum cell counts in stable chro -nic obstructive pulmonary disease (SCOPD) patients, and explore the correlation between lower airway bacterial colo-nization(LABC) and airway inflammation.Methods 47 patients with SCOPD were chosen ,all patients induced spu-tum specimens to sputum quantitative bacterial culture and sputum cell counts ,sputum and serum IL-8 levels were al-so detected.Results There were 13 patients whose bacterial colonization of the lower respiratory tract in patients was higher than 107CFU/mL.Serum IL-8 levels of 13 patients was ( 70.65 ±19.89 ) pg/mL, sputum IL-8 levels was (364.65 ±74.19)pg/mL,all significantly higher than those whose bacterial colonization of the lower respiratory tract lower than 107CFU/mL,(15.87 ±3.01)pg/mL and (146.65 ±28.11)pg/mL,there were statistically significant difference(t=13.43,9.76,all P<0.05).After 1-year follow-up,FEV1 decline(0.071 ±0.016)L in patients whose bacterial colonization of the lower respiratory tract≥107CFU/mL,it was significantly higher than those whose bacterial colonization of the lower respiratory tract <107CFU/mL;the frequency of acute exacerbation was (2.93 ±1.07) times,significantly more than those whose bacterial colonization of the lower respiratory tract <107CFU/mL,the differ-ences were statistically significant (t=5.43,6.54,all P<0.05).Conclusion Lower respiratory tract bacterial colo-nization in patients with SCOPD can aggravate the inflammatory response and increase degree of airflow limitation .
