CAJ | 학술논문

目的：探讨盐酸利托君与硫酸镁治疗先兆早产的疗效及对胎儿纤维连接蛋白（ fFN）的影响。方法选择368例先兆早产产妇，按照随机-平行对照法分为盐酸利托君治疗组（简称观察组）以及硫酸镁治疗组（简称对照组），观察两组疗效、胎儿纤维连接蛋白阳性率并评价其安全性。结果与对照组比较，观察组药物起效时间、缩短明显，妊娠延长天数、治疗成功比例增加明显，差异均有统计学意义（ t＝103．4、9．6，χ2＝12．0，均P＜0．05）。治疗前，两组fFN阳性率差异无统计学意义（χ2＝0．4，P＞0.05），治疗后观察组fFN阳性率为28．26％，对照组为42．39％，两组差异有统计学意义（χ2＝8．0，P＜0.05）。观察组不良反应发生率（19.57％）显著低于对照组（29．35％）（χ2＝4．8，P＜0．05）。结论盐酸利托君治疗先兆早产疗效较佳，可缩短药物起效时间，延长妊娠天数，而且可显著降低fFN阳性率，具有较好的安全性。
목적：탐토염산리탁군여류산미치료선조조산적료효급대태인섬유련접단백（ fFN）적영향。방법선택368례선조조산산부，안조수궤-평행대조법분위염산리탁군치료조（간칭관찰조）이급류산미치료조（간칭대조조），관찰량조료효、태인섬유련접단백양성솔병평개기안전성。결과여대조조비교，관찰조약물기효시간、축단명현，임신연장천수、치료성공비례증가명현，차이균유통계학의의（ t＝103．4、9．6，χ2＝12．0，균P＜0．05）。치료전，량조fFN양성솔차이무통계학의의（χ2＝0．4，P＞0.05），치료후관찰조fFN양성솔위28．26％，대조조위42．39％，량조차이유통계학의의（χ2＝8．0，P＜0.05）。관찰조불량반응발생솔（19.57％）현저저우대조조（29．35％）（χ2＝4．8，P＜0．05）。결론염산리탁군치료선조조산료효교가，가축단약물기효시간，연장임신천수，이차가현저강저fFN양성솔，구유교호적안전성。
Objective To discuss curative effect between ritodrine hydrochloride and magnesium sulfate treated with threatened premature labor and its effect to fetal fibronectin .Methods 368 cases threatened premature labor puerperants were selected and randomly divided into the ritodrine hydrochloride treatment group ( short for obser-vation group) and magnesium sulfate treatment group (short for control group),The two group puerperants′curative effect,changes of fetal fibronectin positive rate and safety evaluation were observed .Results Compared with the con-trol group,the observation group′s medicine effect time ,treatment failure proportion obviously decreased;prolongation pregnancy days,treatment success proportion obviously increased ,the differences all had statistical significances (t=103.4,9.6,χ2 =12.0,all P<0.05).Before the treatment,compared the two groups′fFN positive rates,the differ-ences hadn′t statistical significances(χ2 =0.4,P>0.05);after the treatment,the observation group′s fFN positive rates was 28.26%,wich of the control group was 42.39%,compared the two groups′fFN positive rates,the observa-tion group obviously decreased ,the differences had statistical significances (χ2 =8.0,P <0.05).The observation group′s untoward effect rate was 1 9 .5 7%, which was lower than that of the control group (χ2 =4 .8 , P<0 .0 5 ) .Conclusion Ritodrine hydrochloride treated with threatened premature labor not only can get good treatment effect , shorten medicine effect time ,prolong pregnancy days;but also can obviously decrease fetal fibronectin positive rate , which has good safety ,and is suitable for clinical application .