CAJ | 학술논문

目的：观察三七总皂苷联合银杏黄酮对高脂血症大鼠脂代谢和促炎因子的影响，并探讨其临床意义。方法24只大鼠随机分为对照组（n=8）和高脂喂养组（n=16），高脂喂养组通过高脂、高胆固醇饮食建立高脂血症大鼠模型；8周后高脂喂养组又随机分为高脂血症组（n=8）和给药组（n=8），给药组继续给予高脂饮食的同时予以三七总皂苷（100 mg?kg-1?d-1）和银杏黄酮（48 mg?kg-1?d-1）灌胃8周。之后检测各组大鼠肝重/体重比、附睾脂肪重量/体重比，并检测血浆炎性因子IL-6、TNF-α、hs-CRP的变化。结果高脂血症组大鼠肝重/体重比、附睾脂肪重量/体重比较对照组明显升高（P＜0.01），血浆促炎因子IL-6、TNF-α、hs-CRP水平较正常对照组明显升高（P＜0.01）；而与高脂血症组大鼠比较，给药组大鼠肝重/体重比、附睾脂肪重量/体重比明显降低（P＜0.05），血浆炎性因子IL-6、TNF-α、hs-CRP水平显著下降（P＜0.05）。结论三七总皂苷和银杏黄酮联合给药能有效地改善高脂血症大鼠脂代谢紊乱，同时具有显著的抗炎作用。
목적：관찰삼칠총조감연합은행황동대고지혈증대서지대사화촉염인자적영향，병탐토기림상의의。방법24지대서수궤분위대조조（n=8）화고지위양조（n=16），고지위양조통과고지、고담고순음식건립고지혈증대서모형；8주후고지위양조우수궤분위고지혈증조（n=8）화급약조（n=8），급약조계속급여고지음식적동시여이삼칠총조감（100 mg?kg-1?d-1）화은행황동（48 mg?kg-1?d-1）관위8주。지후검측각조대서간중/체중비、부고지방중량/체중비，병검측혈장염성인자IL-6、TNF-α、hs-CRP적변화。결과고지혈증조대서간중/체중비、부고지방중량/체중비교대조조명현승고（P＜0.01），혈장촉염인자IL-6、TNF-α、hs-CRP수평교정상대조조명현승고（P＜0.01）；이여고지혈증조대서비교，급약조대서간중/체중비、부고지방중량/체중비명현강저（P＜0.05），혈장염성인자IL-6、TNF-α、hs-CRP수평현저하강（P＜0.05）。결론삼칠총조감화은행황동연합급약능유효지개선고지혈증대서지대사문란，동시구유현저적항염작용。
Objective To investigate the synergetic effects of panax notoginseng saponins (PNS) and ginkgetin on proinflammatory cytokines in rats with hyperlipidemia, and explore the clinical significance. Methods 24 Wistar rats were randomly divided into two groups: the control group (n=8) fed with standard laboratory chow and the high-fat diet group (n=16) fed with high-lard/cholesterol diet (83%standard laboratory chow, 2%cholesterol, 10%lard and 5%powder of vitellus). 8 weeks later, the high-fat diet group was further divided into two groups:the hyperlipidemic group (n=8) and the drug-treated group (n=8). The drug-treated group was administered with PNS (100 mg?kg-1?d-1) and ginkgetin (48 mg?kg-1?d-1) for another two months. At the end of the treatment, the ratio of liver weight/body weight and testicular fat weight/body weight were measured, and the change of plasma proinflammatory cytokine such as IL-6, TNF-αand hs-CRP were determined. Results In hyperlipidemic group, the ratio of liver weight/body weight and testicular fat weight/body weight were significantly higher than control group (P<0.01), and the plasma proinflammatory cytokine level of IL-6, TNF-αand hs-CRP were elevated (P<0.01), but these parameters were dramatically decreased in drug-treated group as compared with hyperlipidemic group (P<0.05). Conclusion PNS and ginkgetin have synergetic functions to effectively improve lipid metabolism, and have significant anti-inflammatory effects.