CAJ | 학술논문

目的：探讨辛伐他汀联合依折麦布对动脉粥样硬化的ApoE-/-小鼠血清炎性因子的影响。方法高脂饲料喂养ApoE-/-小鼠，建立动脉粥样硬化模型。将动脉粥样硬化的ApoE-/-小鼠30只随机分为3组。模型组不给药；单药治疗组给予辛伐他汀片20 mg?kg-1?d-1；联合治疗组给予辛伐他汀20 mg?kg-1?d-1及依折麦布片5 mg?kg-1?d-1，野生的普通C57小鼠10只作为对照组。给药4周后，酶法检测血清HDL-C、LDL-C、总胆固醇及甘油三酯。ELISA法检测各组血清TNF-α及MCP-1含量。结果与单药治疗组比较，联合治疗组更有效降低总胆固醇、甘油三酯、LDL-C，更显著降低TNF-α及MCP-1，差异有统计学意义。结论依折麦布与辛伐他汀联用较单用辛伐他汀可强化降脂、减轻炎症反应，发挥抗动脉粥样硬化作用。
목적：탐토신벌타정연합의절맥포대동맥죽양경화적ApoE-/-소서혈청염성인자적영향。방법고지사료위양ApoE-/-소서，건립동맥죽양경화모형。장동맥죽양경화적ApoE-/-소서30지수궤분위3조。모형조불급약；단약치료조급여신벌타정편20 mg?kg-1?d-1；연합치료조급여신벌타정20 mg?kg-1?d-1급의절맥포편5 mg?kg-1?d-1，야생적보통C57소서10지작위대조조。급약4주후，매법검측혈청HDL-C、LDL-C、총담고순급감유삼지。ELISA법검측각조혈청TNF-α급MCP-1함량。결과여단약치료조비교，연합치료조경유효강저총담고순、감유삼지、LDL-C，경현저강저TNF-α급MCP-1，차이유통계학의의。결론의절맥포여신벌타정련용교단용신벌타정가강화강지、감경염증반응，발휘항동맥죽양경화작용。
Objective To investigate the effects of coadministration of Atorvastatin with Ezetimibe on serum inflammatory factors in atherosclerosis ApoE-/-mice. Methods Thirty ApoE-/-mice were treated with high cholesterol diet 8 weeks to set up atherosclerosis model. Then, thirty ApoE-/-atherosclerotic mice were randomly divided into 3 groups:model group (n=10), Simvastatin treatment group (n=10), and coadministration group (n=10) and respectively treated with no drug, Simvastatin 20 mg?kg-1?d-1, and Simvastatin 20 mg?kg-1?d-1+Ezetimibe 5 mg?kg-1?d-1 for 4 weeks. 10 common wild C57 mice served as control group. Serum lipid level(TG, TC, HDL-C and LDL-C) was measured by enzymatic method. Serum TNF-αand MCP-1 level were measured by ELISA. Results Compared with simvastatin treatment group, the coadministration of Ezetimibe could better decrease the level of serum TC, TG, LDL-C, TNF-αand MCP-1. There was significant difference between Simvastatin group and coadministration group. Conclusion The coadministration of Simvastain and Ezetimibe may play a good role in anti-atherosclerosis by decreasing the level of serum TC, TG and LDL-C and reducing the inflammation reaction.