CAJ | 학술논문

目的：了解不同胰岛素治疗方案及注射装置对1型糖尿病( T1DM)患者血糖控制的影响。方法：横断面调查在中山市登记的T1DM患者的临床资料，收集的血、尿标本；比较胰岛素泵组、胰岛素笔式注射器(胰岛素多次皮下注射组和混合胰岛素皮下注射组)、注射器组的HbA1c水平。结果：共调查168例T1DM患者，其中43例(25.6％)达到相应年龄的血糖控制目标。胰岛素泵组、胰岛素笔式注射器(胰岛素多次皮下注射组和混合胰岛素皮下注射组)、注射器组患者的HbA1c水平比较，差异无统计学意义(P>0.05)；HbA1c与胰岛素用量呈正相关，与体质指数(BMI)、就诊次数、自我血糖监测(SMBG)频率、病程、年龄呈负相关( P<0.05)。结论：参与调查的T1DM患者血糖控制差；选择不同胰岛素治疗方案及注射装置对血糖控制无影响；适当增加患者体质量、增加就诊次数及血糖监测频率有助血糖控制。
목적：료해불동이도소치료방안급주사장치대1형당뇨병( T1DM)환자혈당공제적영향。방법：횡단면조사재중산시등기적T1DM환자적림상자료，수집적혈、뇨표본；비교이도소빙조、이도소필식주사기(이도소다차피하주사조화혼합이도소피하주사조)、주사기조적HbA1c수평。결과：공조사168례T1DM환자，기중43례(25.6％)체도상응년령적혈당공제목표。이도소빙조、이도소필식주사기(이도소다차피하주사조화혼합이도소피하주사조)、주사기조환자적HbA1c수평비교，차이무통계학의의(P>0.05)；HbA1c여이도소용량정정상관，여체질지수(BMI)、취진차수、자아혈당감측(SMBG)빈솔、병정、년령정부상관( P<0.05)。결론：삼여조사적T1DM환자혈당공제차；선택불동이도소치료방안급주사장치대혈당공제무영향；괄당증가환자체질량、증가취진차수급혈당감측빈솔유조혈당공제。
Objective:To assess the influences of different treatment protocols and injection instruments on blood glycemic control in patients with type 1 diabetes mellitus ( T1DM) . Methods:A survey was conducted on the T1DM patients in Zhongshan city. We recorded the clinical profiles and collected blood and urine samples for a cross-sectional investigation. This entailed comparison on the levels of glycosylated hemoglobin ( HbA1c ) between patients treated with continuous subcutaneous insulin infusion ( CSII),the insulin pen injector ( multiple daily injections and premixed insulin injection) and the conventional injector. Results: Of the 168 patients who were surveyed,43 ( 25. 6%) achieved the age-specific target levels. The difference in HbA1c among the three groups was unremarkable ( P>0.05) . The HbA1c was positively correlated with insulin dosage administered per day and inversely correlated with the body mass index, the frequency of out-patient clinic visits, frequency of self-monitoring of blood glucose,the duration of T1DM and the age ( all P<0.05) . Conclusion: T1DM patients did not achieved the targeted level of blood glucose control in our survey. The therapeutic effects of different routes for insulin treatment did not significantly influence on the blood glucose levels. Glucose control could be better achieved via a certain magnitude of increase in the body-mass index and the frequency of out-patient clinic visits and self-monitoring of blood glucose levels.