中华实验和临床感染病杂志(电子版)
中華實驗和臨床感染病雜誌(電子版)
중화실험화림상감염병잡지(전자판)
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2014年
3期
410-413
,共4页
强春倩%荆国红%徐学彩%杨友道
彊春倩%荊國紅%徐學綵%楊友道
강춘천%형국홍%서학채%양우도
EB病毒%感染%肝炎%临床特点%预后
EB病毒%感染%肝炎%臨床特點%預後
EB병독%감염%간염%림상특점%예후
Epstein-Barrvirus%Infection%Hepatitis%Clinical features%Prognosis
目的:回顾性观察单纯性EB病毒(EBV)感染引起肝功能损伤患者的临床特点、肝功能变化及预后。方法回顾性分析本院2004年8月至2012年8月诊治的104例EB病毒感染所致肝损害患者。根据流行病学史、病毒学、血清学和肝脏影像学检查等,所有患者均排除了其他原因引起的肝功能损伤,观察患者肝脏生化指标、凝血机制、血液常规和腹部超声等,了解患者的临床特点以及预后。结果本研究104例患者中,男性54例,女性50例,平均年龄37.33岁;平均发病天数为17.51 d,最早的发病后2 d即出现转氨酶增高,患者丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)水平均升高,分别为正常值的19倍和11倍;γ-谷氨酰转移酶(γ-GT)增高至正常值的3.5倍,碱性磷酸酶(ALP)有不同程度的升高。血总胆红素(TBil)异常者70例(67.3%),最高达426.5μmol/L。TBil与GGT、ALP水平均呈正相关关系(r =0.374、P<0.001,r =0.328,P=0.001);ALP和GGT呈正相关关系(r =0.525、P<0.001)。4例患者凝血酶原时间活动度(PTA)低于40%,3例患者行人工肝血浆置换治疗。7例患者发展为慢性肝炎,最长时间维持2年1个月。所有患者预后良好,肝功能均恢复正常。无死亡病例,无1例发展为肝硬化。结论 EBV感染所致肝能损伤为自限性肝炎,可引起胆汁淤积,少数可发展为慢性肝炎及肝功能衰竭。
目的:迴顧性觀察單純性EB病毒(EBV)感染引起肝功能損傷患者的臨床特點、肝功能變化及預後。方法迴顧性分析本院2004年8月至2012年8月診治的104例EB病毒感染所緻肝損害患者。根據流行病學史、病毒學、血清學和肝髒影像學檢查等,所有患者均排除瞭其他原因引起的肝功能損傷,觀察患者肝髒生化指標、凝血機製、血液常規和腹部超聲等,瞭解患者的臨床特點以及預後。結果本研究104例患者中,男性54例,女性50例,平均年齡37.33歲;平均髮病天數為17.51 d,最早的髮病後2 d即齣現轉氨酶增高,患者丙氨痠氨基轉移酶(ALT)和天門鼕氨痠氨基轉移酶(AST)水平均升高,分彆為正常值的19倍和11倍;γ-穀氨酰轉移酶(γ-GT)增高至正常值的3.5倍,堿性燐痠酶(ALP)有不同程度的升高。血總膽紅素(TBil)異常者70例(67.3%),最高達426.5μmol/L。TBil與GGT、ALP水平均呈正相關關繫(r =0.374、P<0.001,r =0.328,P=0.001);ALP和GGT呈正相關關繫(r =0.525、P<0.001)。4例患者凝血酶原時間活動度(PTA)低于40%,3例患者行人工肝血漿置換治療。7例患者髮展為慢性肝炎,最長時間維持2年1箇月。所有患者預後良好,肝功能均恢複正常。無死亡病例,無1例髮展為肝硬化。結論 EBV感染所緻肝能損傷為自限性肝炎,可引起膽汁淤積,少數可髮展為慢性肝炎及肝功能衰竭。
목적:회고성관찰단순성EB병독(EBV)감염인기간공능손상환자적림상특점、간공능변화급예후。방법회고성분석본원2004년8월지2012년8월진치적104례EB병독감염소치간손해환자。근거류행병학사、병독학、혈청학화간장영상학검사등,소유환자균배제료기타원인인기적간공능손상,관찰환자간장생화지표、응혈궤제、혈액상규화복부초성등,료해환자적림상특점이급예후。결과본연구104례환자중,남성54례,녀성50례,평균년령37.33세;평균발병천수위17.51 d,최조적발병후2 d즉출현전안매증고,환자병안산안기전이매(ALT)화천문동안산안기전이매(AST)수평균승고,분별위정상치적19배화11배;γ-곡안선전이매(γ-GT)증고지정상치적3.5배,감성린산매(ALP)유불동정도적승고。혈총담홍소(TBil)이상자70례(67.3%),최고체426.5μmol/L。TBil여GGT、ALP수평균정정상관관계(r =0.374、P<0.001,r =0.328,P=0.001);ALP화GGT정정상관관계(r =0.525、P<0.001)。4례환자응혈매원시간활동도(PTA)저우40%,3례환자행인공간혈장치환치료。7례환자발전위만성간염,최장시간유지2년1개월。소유환자예후량호,간공능균회복정상。무사망병례,무1례발전위간경화。결론 EBV감염소치간능손상위자한성간염,가인기담즙어적,소수가발전위만성간염급간공능쇠갈。
Objective To investigate the Epstein-Barr virus (EBV) infection causes liver damage in patients with clinical features and prognosis of liver function, retrospectively.Method The data of 104 cases with liver damage caused by EB virus infection from August 2004 to August 2012 in our hospital were analyzed, retrospectively. According to epidemiological history, virology, serology and liver image, etc, all patients were ruled out other causes of liver injury. Observed in patients with liver biochemistry, blood clotting mechanisms, routine blood and abdominal ultrasound, in order to analyze the patients’ clinical features and prognosis.Result Among the 104 patients, there were male 54 cases, female 50 cases, with an average age of 37.33 years, with the mean number of days of onset was 17.51 d. The ifrst two days of onset appears elevated transaminase. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) of the 104 patients were elevated with 19 times and 11 times the normal value, respectively. The levels of γ- glutamyl transferase (γ-GT) increased to 3.5 times of the normal value. Alkaline phosphatase (ALP) had exaltation in varying degrees. Serum bilirubin (TBil) abnormal with 70 (67.3%) cases, up to 426.5 μmol/L. The levels of TBil and GGT, ALP were with positively correlated (r= 0.374,P < 0.001;r = 0.328,P < 0.001). The levels of ALP and GGT were positively correlated (r = 0.525,P < 0.001). There were 4 patients’ with prothrombin time activity (PTA) less than 40% while 3 cases underwent plasma exchange therapy. There were 7 patients develop chronic hepatitis, most maintain for 2-year and 1 month. All patients had good prognosis, all with liver function returned to normal. Among the 104 cases, there were no deaths and no cases develop cirrhosis.Conclusions Liver damage caused by EBV infection could cause is self-limited hepatitis, could cause cholestasis, a few patients may develop to chronic hepatitis and liver failure.