中华实验和临床感染病杂志(电子版)
中華實驗和臨床感染病雜誌(電子版)
중화실험화림상감염병잡지(전자판)
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2014年
3期
379-383
,共5页
幽门螺杆菌%益生菌%Meta分析%根除率%不良反应
幽門螺桿菌%益生菌%Meta分析%根除率%不良反應
유문라간균%익생균%Meta분석%근제솔%불량반응
Helicobacter Pylori%Probiotics%Meta-analysis%Eradication rate%Side effects
目的:系统评价益生菌联合三联疗法在根除幽门螺杆菌(Hp)及降低胃肠道不良反应中的疗效。方法从常用电子数据库中检索益生菌联合三联疗法与单独三联疗法根除Hp的随机临床试验,分析各项研究的根除率与不良反应发生率的合并RR值,行敏感性分析,用漏斗图检查发表偏移。结果共12项随机临床试验(2480例)符合纳入标准,益生菌联合三联疗法与单独三联疗法按意向治疗分析(ITT)Hp根除率分别为:79.8%(95%CI:0.65~0.91)和67.3%(95%CI:0.50~0.81),合并RR值为1.14(95%CI:1.09~1.19),P<0.05。两种疗法的不良反应发生率分别为:13.2%(95%CI:0.03~0.41)和25.5%(95%CI:0.04~0.58),合并RR值为0.50(95%CI:0.31~0.81),P<0.05。结论益生菌可以提高三联疗法对Hp的根除率,同时降低胃肠道不良反应的发生率。
目的:繫統評價益生菌聯閤三聯療法在根除幽門螺桿菌(Hp)及降低胃腸道不良反應中的療效。方法從常用電子數據庫中檢索益生菌聯閤三聯療法與單獨三聯療法根除Hp的隨機臨床試驗,分析各項研究的根除率與不良反應髮生率的閤併RR值,行敏感性分析,用漏鬥圖檢查髮錶偏移。結果共12項隨機臨床試驗(2480例)符閤納入標準,益生菌聯閤三聯療法與單獨三聯療法按意嚮治療分析(ITT)Hp根除率分彆為:79.8%(95%CI:0.65~0.91)和67.3%(95%CI:0.50~0.81),閤併RR值為1.14(95%CI:1.09~1.19),P<0.05。兩種療法的不良反應髮生率分彆為:13.2%(95%CI:0.03~0.41)和25.5%(95%CI:0.04~0.58),閤併RR值為0.50(95%CI:0.31~0.81),P<0.05。結論益生菌可以提高三聯療法對Hp的根除率,同時降低胃腸道不良反應的髮生率。
목적:계통평개익생균연합삼련요법재근제유문라간균(Hp)급강저위장도불량반응중적료효。방법종상용전자수거고중검색익생균연합삼련요법여단독삼련요법근제Hp적수궤림상시험,분석각항연구적근제솔여불량반응발생솔적합병RR치,행민감성분석,용루두도검사발표편이。결과공12항수궤림상시험(2480례)부합납입표준,익생균연합삼련요법여단독삼련요법안의향치료분석(ITT)Hp근제솔분별위:79.8%(95%CI:0.65~0.91)화67.3%(95%CI:0.50~0.81),합병RR치위1.14(95%CI:1.09~1.19),P<0.05。량충요법적불량반응발생솔분별위:13.2%(95%CI:0.03~0.41)화25.5%(95%CI:0.04~0.58),합병RR치위0.50(95%CI:0.31~0.81),P<0.05。결론익생균가이제고삼련요법대Hp적근제솔,동시강저위장도불량반응적발생솔。
Obejective To systematically evaluate the effect of supplement of probiotics to standard triple therapy on the eradication rate and side-effects of anti-Helicobacter Pylori (Hp) treatment.Methods Publications of ramdamized clinical trails on the triple therapy or probiotics combined with triple therapy to eradicate Hp were searched using electronic databases. The relative risk (RR) of HP eradication rate and rate of side effects were analysed. Sensitivity analysis was also performed. The publication bias were tested by funnel plot. Results Total of 12 randomized clinical trials including 2 480 cases were identiifed. According to intention-to-treat (ITT) analysis, for patients with or without probiotics, Hp eradication rate was 79.8% (95%CI: 0.65-0.91) and 67.3% (95%CI: 0.50-0.81), respectively; RR was 1.14 (95%CI: 1.09-1.19),P< 0.05. For groups with or without probiotics, the occurrence of total side effects were 13.2%(95%CI: 0.03-0.41) and 25.5 (95%CI: 0.04-0.58), respectively; the summary RR was 0.50 (95%CI: 0.31-0.81),P < 0.05.Conclusions Probiotics supplementation is effective in increasing the eradication rate during standard triple therapy for Hp eradication. Furthermore, probiotics show a positive impact on Hp therapy-related side effects.