CAJ | 학술논문

目的：探讨HBV感染对妊娠期急性脂肪肝（AFLP）的发生率及妊娠结局的影响。方法采用回顾性调查方法对HBV感染的AFLP孕妇9例和无HBV感染的AFLP孕妇42例进行对比分析，采用t检验和χ2检验进行统计学分析，观察HBV感染对妊娠期肝内胆汁淤积症（ICP）发生率及妊娠结局的影响。结果伴有HBV感染的AFLP孕妇发生率显著高于一般人群，且其发病时间显著早于无HBV感染的AFLP患者，两者差异均具有统计学意义（P均＜0.05）；伴HBV感染的AFLP孕妇早产发生率、新生儿窒息率、产后出血发生率均显著高于无HBV感染的AFLP孕妇，差异均具有统计学意义（P均＜0.05）。结论 HBV感染可使AFLP的发生率增高，易引起早产、新生儿窒息率及产后出血率增高，应加强对该类患者的孕产期监护和治疗，以保证母婴的健康和安全。
목적：탐토HBV감염대임신기급성지방간（AFLP）적발생솔급임신결국적영향。방법채용회고성조사방법대HBV감염적AFLP잉부9례화무HBV감염적AFLP잉부42례진행대비분석，채용t검험화χ2검험진행통계학분석，관찰HBV감염대임신기간내담즙어적증（ICP）발생솔급임신결국적영향。결과반유HBV감염적AFLP잉부발생솔현저고우일반인군，차기발병시간현저조우무HBV감염적AFLP환자，량자차이균구유통계학의의（P균＜0.05）；반HBV감염적AFLP잉부조산발생솔、신생인질식솔、산후출혈발생솔균현저고우무HBV감염적AFLP잉부，차이균구유통계학의의（P균＜0.05）。결론 HBV감염가사AFLP적발생솔증고，역인기조산、신생인질식솔급산후출혈솔증고，응가강대해류환자적잉산기감호화치료，이보증모영적건강화안전。
ObjectiveTo explore the incidence and inlfuence of HBV infection on the pregnancy outcome of patients withacute fatty liver of pregnancy (AFLP). MethodsBy using review investigation, 9 cases of pregnant women suffered from AFLP with HBV infection and 42 cases of AFLP without HBV infection were compared and analyzed,ttest andχ2 test were used for statistical analysis.The incidence and pregnancy outcome of AFLP between the two groups were observed.Results The incidence of AFLP was higher in pregnant women who were in fected by HBV than those without HBV infection (P< 0.05), the onset time was earlier in the infectedpatientsthan those without HBV infection(P < 0.05), the incidence of premature delivery,neonatal asphyxia and postpartum bleedingwerealso higher in HBV infectionpatients than those without HBV infection(P <0.05).Conclusions HBV infection couldincreasethe incidence of AFLP,prematuredelivery andpostpartum bleeding.Monitoring and treatment of perinatal complications of AFLP should be strengthened for patients with HBV infection.