CAJ | 학술논문

目的：通过对慢性乙型肝炎患者抗病毒治疗前后肝组织病理检查的差异性比较，初步探讨干扰素与核苷（酸）类似物抗病毒治疗效果。方法对29例单独应用干扰素或核苷（酸）类似物治疗的慢性乙型肝炎患者，于治疗前和治疗后48周进行肝组织活检，用半定量系统计分方案对治疗前后肝组织学进行评分，比较治疗前后变化并分析其意义。结果治疗前后相比，HBV DNA完全应答组获得显著的组织学改善。抗病毒治疗48周干扰素与核苷（酸）类似物两种抗病毒方式相比较无差异。结论无论是干扰素或是核苷（酸）类似物抗病毒，获得病毒学完全应答均可明显改善肝脏炎症、纤维化程度，不同机制的抗病毒药物治疗在48周时肝脏组织学变化无明显差异。
목적：통과대만성을형간염환자항병독치료전후간조직병리검사적차이성비교，초보탐토간우소여핵감（산）유사물항병독치료효과。방법대29례단독응용간우소혹핵감（산）유사물치료적만성을형간염환자，우치료전화치료후48주진행간조직활검，용반정량계통계분방안대치료전후간조직학진행평분，비교치료전후변화병분석기의의。결과치료전후상비，HBV DNA완전응답조획득현저적조직학개선。항병독치료48주간우소여핵감（산）유사물량충항병독방식상비교무차이。결론무론시간우소혹시핵감（산）유사물항병독，획득병독학완전응답균가명현개선간장염증、섬유화정도，불동궤제적항병독약물치료재48주시간장조직학변화무명현차이。
Objective To investigate the change of liver histology and evaluate the efifcacy of two kinds of different mechanisms antiviral therapy on patients with chronic hepatitis B (CHB).Methods Liver biopsy tissues were done in 29 CHB patients who adopt interferon therapy or nucleos(t)ide analogues therapy before therapy and 48 weeks later. Histological scores were evaluated according to the semi-quantitative rating system.Results Compared with the liver inlfammation and ifbrosis, HBV DNA completely response group get the histologic improvement significantly. The effect of interferon and nucleos(t)ide analogues therapy are indiscriminate at 48 weeks.Conclusions Whether interferon therapy or nucleos(t)ide analogues therapy which could get virological completely response, get the obvious degree of improvement, and at 48 weeks the two kinds of different mechanisms antiviral therapy efifcacy are indiscriminate.