CAJ | 학술논문

目的：对乙型肝炎病毒（HBV）与血吸虫双重感染伴多形性肝细胞肝癌（HCC）的临床病理特征进行综合分析。方法收集研究对象的临床资料，对1例术后肝肿物及其周围部分肝组织做常规石蜡切片、HE染色及免疫组织化学染色，肉眼及光镜观察。结果镜下见肝肿瘤细胞呈片状或巢团型生长，细胞大小不一，半数以上的癌细胞呈典型的多边形，可见奇异的单核或多核瘤巨细胞，核分裂相易见；肿瘤周围组织见肝硬化及陈旧性血吸虫结节；免疫组织化学显示，肿瘤细胞HepPar1（+）、AFP（+）、CD34微血管（+）、CEA（+）、p53（少数+）、E钙黏蛋白（少数+）；CK7（-）、CK19（-）、VIM（-）、EMA（-）；肿瘤周围部分肝细胞HBsAg呈阳性表达。结论 HBV与血吸虫双重感染对肝癌的发生有协同作用，术后行病理学检查更能准确诊断、客观评价和分析HCC的进程。
목적：대을형간염병독（HBV）여혈흡충쌍중감염반다형성간세포간암（HCC）적림상병리특정진행종합분석。방법수집연구대상적림상자료，대1례술후간종물급기주위부분간조직주상규석사절편、HE염색급면역조직화학염색，육안급광경관찰。결과경하견간종류세포정편상혹소단형생장，세포대소불일，반수이상적암세포정전형적다변형，가견기이적단핵혹다핵류거세포，핵분렬상역견；종류주위조직견간경화급진구성혈흡충결절；면역조직화학현시，종류세포HepPar1（+）、AFP（+）、CD34미혈관（+）、CEA（+）、p53（소수+）、E개점단백（소수+）；CK7（-）、CK19（-）、VIM（-）、EMA（-）；종류주위부분간세포HBsAg정양성표체。결론 HBV여혈흡충쌍중감염대간암적발생유협동작용，술후행병이학검사경능준학진단、객관평개화분석HCC적진정。
ObjectiveTo analyze the clinical pathological features of both HBV and schistosome infection accompanied with pleomorphic hepatocellular carcinoma.Methods The clinical data from one case of patient who after liverneoplasm surgery was collected, Hematoxylin Eosin and immunohistochemical staining were performed on conventional parafifn-embeded tissues of neoplasm and section of normal liver, then these silces under a microscope were observed.Results Tumor cells grew in the flake or nesting patterns, varied in sizes. More than half of the tumor cells presented as typical polygon, bizarre nomonuclear or multinucleated giant cells could be seen, nuclear mitotic ifgures were frequent; and there were obsolete schistosome nodi surrounded with tumor. Immunohistochemistry results showed that HepPar1 (+), AFP (+), CD34 in microvasculature (+), CEA (+),p53 (minority +) and E-cadherin (minority +), CK7 (-), CK19 (-), VIM (-), EMA (-). HBsAg was positive in part of the normal hepatic cells around the tumor. Conclusions HBV and schistosoma infection may facilitate to the development of HCC, and postoperative pathological examination could be more accurate diagnosis, objective evaluation and analyze the process of HCC.