中华肾病研究电子杂志
中華腎病研究電子雜誌
중화신병연구전자잡지
2014年
3期
143-146
,共4页
尿毒症瘙痒症%发病机制%治疗进展
尿毒癥瘙癢癥%髮病機製%治療進展
뇨독증소양증%발병궤제%치료진전
Uremic pruritus%Pathogenesis%Treatment progress
尿毒症瘙痒症严重影响着终末期肾病患者的生活质量，其发病机制较为复杂，治疗效果有限，一直是困扰患者和医生的临床难题。本文介绍了免疫炎症假说、阿片类物质假说、皮肤干燥症、血浆组胺水平、高磷和高钙血症等尿毒症瘙痒症的发病机制；同时探讨了尿毒症瘙痒症的治疗进展。
尿毒癥瘙癢癥嚴重影響著終末期腎病患者的生活質量，其髮病機製較為複雜，治療效果有限，一直是睏擾患者和醫生的臨床難題。本文介紹瞭免疫炎癥假說、阿片類物質假說、皮膚榦燥癥、血漿組胺水平、高燐和高鈣血癥等尿毒癥瘙癢癥的髮病機製；同時探討瞭尿毒癥瘙癢癥的治療進展。
뇨독증소양증엄중영향착종말기신병환자적생활질량，기발병궤제교위복잡，치료효과유한，일직시곤우환자화의생적림상난제。본문개소료면역염증가설、아편류물질가설、피부간조증、혈장조알수평、고린화고개혈증등뇨독증소양증적발병궤제；동시탐토료뇨독증소양증적치료진전。
Uremic pruritus,whose pathogenesis is complex with limited efficacy of treatment, impacts seriously on the life quality of patients with end-stage renal disease,and has always been a problem for both uremic patients and doctors.In this paper,factors involved in the pathogenesis of uremic pruritus have been introduced,including immune inflammation hypothesis,opioid hypothesis,skin xerosis,plasma histamine level,hyperphosphatemia and hypercalcemia,etc.Besides,the treatment progress of uremic pruritus is also discussed.
