CAJ | 학술논문

无机介孔材料是一种孔直径在2~50 nm 的多孔材料。这种材料具有结构规则，机械性能高、化学和热能稳定性好等特点。近年来，随着材料合成技术的提高，不断有新型高负载能力和生物相容性好的介孔材料被开发出来。同时，实验表明，无机介孔材料是固载生物大分子的良好载体。利用无机介孔材料固载氧化还原蛋白质并结合其的直接电子转移，为我们提供了一种新的构建第三代生物传感器的方法。基于无机介孔材料的特点及氧化还原蛋白质的直接电子转移，所构建的第三代电化学生物传感器有望具有较传统电化学传感器更好的性能。将介孔材料分为二氧化硅基和非二氧化硅基2大类，描述了无机介孔材料在第三代电化学生物传感器中的应用。
무궤개공재료시일충공직경재2~50 nm 적다공재료。저충재료구유결구규칙，궤계성능고、화학화열능은정성호등특점。근년래，수착재료합성기술적제고，불단유신형고부재능력화생물상용성호적개공재료피개발출래。동시，실험표명，무궤개공재료시고재생물대분자적량호재체。이용무궤개공재료고재양화환원단백질병결합기적직접전자전이，위아문제공료일충신적구건제삼대생물전감기적방법。기우무궤개공재료적특점급양화환원단백질적직접전자전이，소구건적제삼대전화학생물전감기유망구유교전통전화학전감기경호적성능。장개공재료분위이양화규기화비이양화규기2대류，묘술료무궤개공재료재제삼대전화학생물전감기중적응용。
Inorganic mesoporous materials are porous inorganic materials with pores diameters between 2 and 50 nm. The inorganic mesoporous materials are more attractive because of their regular structure,good mechanical,chemical and thermal stability.In recent years,inorganic mesoporous materials show great potential for use in biosensing because it provides a promising method to develop nanostructured materials that enable high loading and long-term stability of the biomolecules.In addition,the porosity and stability of the host was also advantageous to improve the performance of biosensor.Development of the third-generation biosensors based on the direct electron transfer of redox proteins in biosensing is significant,because it provides models for mechanism study of biological electron transport and enables to establish mediator-free (the third generation)biosensors and bioreactors.Taking advantage of characteristics of inorganic mesoporous materials,its application as the supports for proteins and enzymes in the third-generation electrochemical biosensors gives the new way to fabricate the biosensor and offers the chance to improve the performance of the biosensor. In this report,we classify the mesoporous host into two kinds by constituent,silica based and non-silica based.The recent work in the third generation biosensor area by inorganic mesoporous materials is reviewed.