山西中医学院学报
山西中醫學院學報
산서중의학원학보
JOURNAL OF SHANXI COLLEGE OF TRADITIONAL CHINESE MEDICINE
2014年
3期
27-28,68
,共3页
补中益气汤%运动性疲劳%超氧化物歧化酶%谷胱甘肽过氧化物酶%丙二醛
補中益氣湯%運動性疲勞%超氧化物歧化酶%穀胱甘肽過氧化物酶%丙二醛
보중익기탕%운동성피로%초양화물기화매%곡광감태과양화물매%병이철
Buzhong Yiqi decoction%exercise induced fatigue%SOD%GSH-XP%MDA
目的：探讨补中益气汤对运动性疲劳大鼠血清超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-XP）、丙二醛（MDA）含量的影响。方法：48只大鼠随机分为空白对照组、模型组、补中益气汤小剂量组（小剂量组）、补中益气汤大剂量组（大剂量组）4组，每组12只。空白对照组不做任何运动，其他各组每天灌胃2 h后进行无负重游泳训练。同时大剂量组大鼠按体重灌服补中益气汤12 g/kg；小剂量组大鼠灌服补中益气汤6 g/kg；空白对照组和模型组灌服同体积纯化水。1次/d，连续6 w。第6周末，按照试剂盒说明书检测各组大鼠SOD、MDA、GSH-XP含量。结果：与空白对照组相比，模型组、补中益气汤大、小剂量组MDA、SOD、GSH-XP含量升高。与模型组比较，补中益气汤大、小剂量组MDA含量明显下降（P<0.05），GSH-XP含量升高（P<0.05）。结论：补中益气汤能够提高血清GSH-PX、SOD的活性，降低MDA含量，从而提高机体抗疲劳能力。
目的：探討補中益氣湯對運動性疲勞大鼠血清超氧化物歧化酶（SOD）、穀胱甘肽過氧化物酶（GSH-XP）、丙二醛（MDA）含量的影響。方法：48隻大鼠隨機分為空白對照組、模型組、補中益氣湯小劑量組（小劑量組）、補中益氣湯大劑量組（大劑量組）4組，每組12隻。空白對照組不做任何運動，其他各組每天灌胃2 h後進行無負重遊泳訓練。同時大劑量組大鼠按體重灌服補中益氣湯12 g/kg；小劑量組大鼠灌服補中益氣湯6 g/kg；空白對照組和模型組灌服同體積純化水。1次/d，連續6 w。第6週末，按照試劑盒說明書檢測各組大鼠SOD、MDA、GSH-XP含量。結果：與空白對照組相比，模型組、補中益氣湯大、小劑量組MDA、SOD、GSH-XP含量升高。與模型組比較，補中益氣湯大、小劑量組MDA含量明顯下降（P<0.05），GSH-XP含量升高（P<0.05）。結論：補中益氣湯能夠提高血清GSH-PX、SOD的活性，降低MDA含量，從而提高機體抗疲勞能力。
목적：탐토보중익기탕대운동성피로대서혈청초양화물기화매（SOD）、곡광감태과양화물매（GSH-XP）、병이철（MDA）함량적영향。방법：48지대서수궤분위공백대조조、모형조、보중익기탕소제량조（소제량조）、보중익기탕대제량조（대제량조）4조，매조12지。공백대조조불주임하운동，기타각조매천관위2 h후진행무부중유영훈련。동시대제량조대서안체중관복보중익기탕12 g/kg；소제량조대서관복보중익기탕6 g/kg；공백대조조화모형조관복동체적순화수。1차/d，련속6 w。제6주말，안조시제합설명서검측각조대서SOD、MDA、GSH-XP함량。결과：여공백대조조상비，모형조、보중익기탕대、소제량조MDA、SOD、GSH-XP함량승고。여모형조비교，보중익기탕대、소제량조MDA함량명현하강（P<0.05），GSH-XP함량승고（P<0.05）。결론：보중익기탕능구제고혈청GSH-PX、SOD적활성，강저MDA함량，종이제고궤체항피로능력。
Objective:To study the effect of Buzhong Yiqi decoction on content of SOD、MDA、GSH-XP in serum with ex-ercise induced fatigue rats. Methods:48 rats were divided into blank control group,model group,high-dosage group and low-dosage group of Buzhong Yiqi decoction with 12 rats in each group. Except for Blank control group,the other groups underwent swimming without additional load for 6 weeks. At the same time,high-dosage group and low-dosage group of Buzhong Yiqi decoction were given Buzhong Yiqi decoction respectively,while blank control group and model group were given purified water. After 6 weeks,serum content of SOD、MDA、GSH-XP were measured. Results:Compared with blank control group,serum content of SOD、MDA、GSH-XP in high-dosage group and low-dosage group of Buzhong Yiqi decoc-tion and model group were decreased. Compared with model group,the serum content of MDA in high-dosage group and low-dosage group of Buzhong Yiqi decoction were significantly decreased(P<0.05)and the serum content of GSH-XP were increased(P<0.05). Conclusion:Buzhong Yiqi decoction can increase the activity of GSH-PX and SOD,and decrease the content of MDA so as to enhance anti-fatigue activity of body.
