CAJ | 학술논문

目的：探讨妇科千金胶囊对SD孕鼠胎仔生长发育的影响，对其生殖安全性进行研究。方法：采用健康育龄SD雌鼠为模型系统，研究妇科千金胶囊对啮齿动物胎仔出生后生长发育的毒性，设0.48 g/kg、1.92 g/kg、7.68 g/kg不同剂量组，并设溶剂对照组，对SD孕鼠体内染毒，观察其对健康育龄SD孕鼠F1代仔鼠生长发育状况等。结果：其对F1代仔鼠哺乳期体重、生长发育标志、反射发育标志的成熟、断乳后体重、断乳后自发活动未见明显影响，且对F1代仔鼠的生殖器官发育及生殖功能等指标也未见明显影响。结论：妇科千金胶囊在7.68 g/kg给药剂量范围内对健康育龄SD孕鼠F1代生长发育无明显毒性。
목적：탐토부과천금효낭대SD잉서태자생장발육적영향，대기생식안전성진행연구。방법：채용건강육령SD자서위모형계통，연구부과천금효낭대교치동물태자출생후생장발육적독성，설0.48 g/kg、1.92 g/kg、7.68 g/kg불동제량조，병설용제대조조，대SD잉서체내염독，관찰기대건강육령SD잉서F1대자서생장발육상황등。결과：기대F1대자서포유기체중、생장발육표지、반사발육표지적성숙、단유후체중、단유후자발활동미견명현영향，차대F1대자서적생식기관발육급생식공능등지표야미견명현영향。결론：부과천금효낭재7.68 g/kg급약제량범위내대건강육령SD잉서F1대생장발육무명현독성。
Objective:To observe the effect of Fuke Qianjin capsules on growth of SD rats of F1 generation so as to assess reproductive toxicity of capsule. Methods:The pregnant SD rats were treated with Fuke Qianjin capsules at 0.48 g/kg,1.92 g/kg,7.68 g/kg. Growth indexes of F1 generation SD rats were observed. Results:The body weight during lactation,develop-ment state of growth and reflex,body weight and spontaneous activity after lactation,as well as development state of repro-ductive organs and reproductive function of F1 generation SD rats were not affected by Fuke Qianjin capsules. Conclusions:Reproductive toxicity of Fuke Qianjin capsules for F1 offspring isn′t observed when the dosage is fewer than 7.68 g/kg.