CAJ | 학술논문

目的：研究斜脉暗罗茎提取物对S180荷瘤抗肿瘤作用的影响。方法：制备S180荷瘤小鼠动物模型，于接种肿瘤后第2日始分别隔日腹腔注射生理盐水或0．1、0．2、0．4 mg/kg-1· d-1的斜脉暗罗茎提取物溶液，7天后处死各组小鼠，观察小鼠胸腺、脾、肿瘤的重量及胸腺指数、脾指数、肿瘤指数等指标。结果：0．2和0．4 mg· kg-1· d-1的斜脉暗罗茎提取物与溶剂对照组相比，胸腺指数、脾指数明显增加（P＜0．05；P＜0．01），且肿瘤生长明显缓慢，肿瘤重量明显降低（P＜0．05；P＜0．01）。结论：斜脉暗罗茎提取物能明显抑制S180荷瘤小鼠肿瘤的生长，其作用机制可能是通过增强荷瘤小鼠自身免疫功能来实现。
목적：연구사맥암라경제취물대S180하류항종류작용적영향。방법：제비S180하류소서동물모형，우접충종류후제2일시분별격일복강주사생리염수혹0．1、0．2、0．4 mg/kg-1· d-1적사맥암라경제취물용액，7천후처사각조소서，관찰소서흉선、비、종류적중량급흉선지수、비지수、종류지수등지표。결과：0．2화0．4 mg· kg-1· d-1적사맥암라경제취물여용제대조조상비，흉선지수、비지수명현증가（P＜0．05；P＜0．01），차종류생장명현완만，종류중량명현강저（P＜0．05；P＜0．01）。결론：사맥암라경제취물능명현억제S180하류소서종류적생장，기작용궤제가능시통과증강하류소서자신면역공능래실현。
Objective:To study the anti-tumor effect of Polyalthia plagioneura stem extract on S 180 tumor bearing mice .Method:Saline and different doses of Polyalthia plagioneura extract (0.1, 0.2 and 0.4 mg· kg-1 · d-1 ) were administered by intraperitoneal injec-tion in every other day , starting at the second day after the S 180 tumor models established .The mice are sacrificed seven days later , the weights of thymus , spleen and tumor , and the indexes including thymus index and spleen index , tumor index were observed .Result:Comparing to the control group , indexes of mice in the high dose treating groups (0.2 and 0.4 mg· kg-1 · d-1 of Polyalthia plagioneu-ra extract) like thymus index and spleen index are increased significantly , and the tumor growth rates are slower and the weight is light-er than in the control group (P<0.05; P<0.01).Conclusion: Polyalthia plagioneura extract can inhibit the tumor growth of S 180 tumor bearing mice , the mechanism may be achieved by enhancing the immune function of mice themselves .