CAJ | 학술논문

棒状体蛋白是弓形虫分泌于宿主细胞的主要效应因子，定位于宿主细胞的不同部位，并与其存在复杂的相互作用。通过调控膜系及骨架结构，该蛋白可影响宿主细胞的生物活性因子，从而阻断其内在的防御机制，使弓形虫成功实现胞内入侵、寄生及增殖。棒状体蛋白对宿主细胞的功能及作用方式反映了弓形虫的致病机制，对探寻治疗弓形虫病的药物靶点及安全有效的疫苗候选分子意义重大。本文就近年来弓形虫棒状体蛋白与宿主细胞间相互作用的研究进展进行综述。
봉상체단백시궁형충분비우숙주세포적주요효응인자，정위우숙주세포적불동부위，병여기존재복잡적상호작용。통과조공막계급골가결구，해단백가영향숙주세포적생물활성인자，종이조단기내재적방어궤제，사궁형충성공실현포내입침、기생급증식。봉상체단백대숙주세포적공능급작용방식반영료궁형충적치병궤제，대탐심치료궁형충병적약물파점급안전유효적역묘후선분자의의중대。본문취근년래궁형충봉상체단백여숙주세포간상호작용적연구진전진행종술。
Rhoptry proteins are the major virulence factors of Toxoplasma gondii. They locate in different parts of the host cells and can affect the membrane cytoskeleton structure and active factors of the host cells so as to block the cell intrinsic de-fense mechanisms of the host and let T. gondii invade parasitize and proliferate in the host successfully. The function and ac-tion mode of rhoptry proteins reflect the pathogenic mechanism of T. gondii which holds great significance to looking for toxo-plasmosis drug targets and developing molecule vaccines. This paper reviews the research progess of the interaction between rhoptry proteins of T. gondii and host cells.