CAJ | 학술논문

研究了用4-特辛基酚、乙酰氯、三氯化铝、盐酸羟胺、异辛酸为原料，用四氯乙烷为溶剂，经3步反应合成2-羟基-5-特辛基苯乙酮肟。在AlCl3作用下，乙酸-（4-特辛基）-苯酯经过Fries重排合成2-羟基-5-特辛基苯乙酮，其优化的合成条件为：以四氯乙烷为溶剂，n（AlCl3）∶ n（4-特辛基酚）＝1．2∶1，反应温度120℃，反应时间6 h。该条件下，2-羟基-5-特辛基苯乙酮的合成产率为90．8％（以辛基酚计），液相色谱纯度为89．2％。产物经IR、1 H-NM R表征确认。由于特辛基的位阻比壬基的高，相同条件下合成的2-羟基-5-特辛基苯乙酮肟的纯度明显比2-羟基-5-壬基苯乙酮肟高；此外，由于高位阻基团的存在，有望提高其对铜的反萃取性能。
연구료용4-특신기분、을선록、삼록화려、염산간알、이신산위원료，용사록을완위용제，경3보반응합성2-간기-5-특신기분을동우。재AlCl3작용하，을산-（4-특신기）-분지경과Fries중배합성2-간기-5-특신기분을동，기우화적합성조건위：이사록을완위용제，n（AlCl3）∶ n（4-특신기분）＝1．2∶1，반응온도120℃，반응시간6 h。해조건하，2-간기-5-특신기분을동적합성산솔위90．8％（이신기분계），액상색보순도위89．2％。산물경IR、1 H-NM R표정학인。유우특신기적위조비임기적고，상동조건하합성적2-간기-5-특신기분을동우적순도명현비2-간기-5-임기분을동우고；차외，유우고위조기단적존재，유망제고기대동적반췌취성능。
Using 4-tert-octylphenol ,CH3COCl ,AlCl3 ,NH2 OH · HCl ,2-ethylhexanoic acid as reactants and tetrachlor-ethane as solvent ,2-hydroxy-5-t-octylacetophenone oxime is synthesized through three steps of reaction .The key step is the Fries of 4-tert-octylphenyl acetate under the catalysis of AlCl3 . The optimal synthesis conditions which affords 2-hydroxy-5-t-octylacetophenone of 90 .8% yields and 89 .2% purities are as follows :n(AlCl3 )∶ n(4-tert-octylpheno)= 1 .2∶1 ,θ= 120 ℃ ,t= 6 h .The structure of the product is identified by IR and 1 H-NMR . The purity of 2-hydroxy-5-t-octylacetophenone oxime is obviously higher than the nonyl-product under the same synthesis conditions presumably due to the high steric hindrance of tert-octyl .T he produce is hopeful to improve the striping performance as copper extractant .