CAJ | 학술논문

目的：探讨本地区ABO血型不合孕妇产前抗体效价检测在预测新生儿溶血病(HDN)中的意义。方法对536名血型不合的O型及Rh阴性孕妇在妊娠20周时进行血型不规则抗体筛选，抗体效价检测，效价≥64的定期(每4周)进行血型抗体效价复查检测,对新生儿出生后(0~7d)出现黄疸症状的抽静脉血3 ml进行血型血清学和溶血病三项检测。结果在536名孕妇血清中检出血型抗体303例，占56.5%，其中IgG抗体≥64者175例，占32.6%；,7名Rh阴性孕妇血清中产生抗D抗体3例，占0.6%；新生儿发生黄疸303例，诊断HDN 73例，占24.1%，接受治疗后均痊愈出院。结论汕头地区孕母产前血型抗体效价与新生儿溶血病密切相关，定期筛选与测定孕母体内血型抗体效价可预测HDN的发生，评估HDN的严重程度及提高HDN的治愈率。
목적：탐토본지구ABO혈형불합잉부산전항체효개검측재예측신생인용혈병(HDN)중적의의。방법대536명혈형불합적O형급Rh음성잉부재임신20주시진행혈형불규칙항체사선，항체효개검측，효개≥64적정기(매4주)진행혈형항체효개복사검측,대신생인출생후(0~7d)출현황달증상적추정맥혈3 ml진행혈형혈청학화용혈병삼항검측。결과재536명잉부혈청중검출혈형항체303례，점56.5%，기중IgG항체≥64자175례，점32.6%；,7명Rh음성잉부혈청중산생항D항체3례，점0.6%；신생인발생황달303례，진단HDN 73례，점24.1%，접수치료후균전유출원。결론산두지구잉모산전혈형항체효개여신생인용혈병밀절상관，정기사선여측정잉모체내혈형항체효개가예측HDN적발생，평고HDN적엄중정도급제고HDN적치유솔。
Objective To investigate the value of ABO antibody titer of pregnant women with ABO blood group incompatibili-ty in predicting of hemolytic disease of the newborn (HDN). Methods A total of 536 pregnant women with ABO blood group in-compatibility and Rh negative were selected. At 20 weeks of gestation, blood group antibody titer was detected. The women with titer ≥64 were rechecked every 4 weeks until delivery. The newborns with jaundice in 0-7 days after birth were checked with blood group and hemolysis diseases test. Results In 536 cases, 303 pregnant women had blood group antibody, accounting for 56.5%. 175 cases had IgG antibody titer≥64, accounting for 32.6%. In 7 cases with Rh negative, 3 women (0.3%) were tested with D antibody. In 303 newborns with neonatal jaundice, 73 cases were proofed with HDN, and all of them were recovered. Con-clusion The pregnant woman blood group antibody is closely related to HDN in Shantou area. Regular screening of blood group an-tibody titer in pregnant women is very important for predicting the occurrence and the severity of HDN, and improving the cure rate of HDN.