实验与检验医学
實驗與檢驗醫學
실험여검험의학
EXPERIMENTAL AND LABORATORY MEDICINE
2014年
4期
398-400,417
,共4页
血脂%非高密度脂蛋白胆固醇%载脂蛋白%冠状动脉疾病
血脂%非高密度脂蛋白膽固醇%載脂蛋白%冠狀動脈疾病
혈지%비고밀도지단백담고순%재지단백%관상동맥질병
Serum lipid%Non-HDL-C%Apolipoproteins%CHD
目的：探讨血清非高密度脂蛋白胆固醇以及载脂蛋白B水平对冠心病的临床应用价值。方法检测118例冠心病(CHD)患者血清三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(apoAl)和载脂蛋白B(apoB)水平，并计算出非高密度脂蛋白胆固醇(non-HDL-C)及apoB/apoA1比值，分析各血脂指标与冠心病的关系。结果 CHD患者血清TG、non-HDL-C和apoB/apoA1比值均高于对照组(P<0.01)，HDL-C和apo Al水平均低于对照组（P<0.01)，差异有统计学意义。 HDL-C和apoA1的诊断灵敏度明显高于TC和LDL-C，而non-HDL-C、apoB以及apoB/apoA1的特异度均较高。结论血清non-HDL-C及apoB/apoA1比值的升高与心血管事件发生危险性明显正相关，其预警价值高于传统指标LDL-C和TC，与冠状动脉粥样硬化病变关系密切，尤其对于LDL-C和TC已经达标者控制其non-HDL-C和apoB水平在冠心病的防治中有重要意义。
目的：探討血清非高密度脂蛋白膽固醇以及載脂蛋白B水平對冠心病的臨床應用價值。方法檢測118例冠心病(CHD)患者血清三酰甘油(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、載脂蛋白A1(apoAl)和載脂蛋白B(apoB)水平，併計算齣非高密度脂蛋白膽固醇(non-HDL-C)及apoB/apoA1比值，分析各血脂指標與冠心病的關繫。結果 CHD患者血清TG、non-HDL-C和apoB/apoA1比值均高于對照組(P<0.01)，HDL-C和apo Al水平均低于對照組（P<0.01)，差異有統計學意義。 HDL-C和apoA1的診斷靈敏度明顯高于TC和LDL-C，而non-HDL-C、apoB以及apoB/apoA1的特異度均較高。結論血清non-HDL-C及apoB/apoA1比值的升高與心血管事件髮生危險性明顯正相關，其預警價值高于傳統指標LDL-C和TC，與冠狀動脈粥樣硬化病變關繫密切，尤其對于LDL-C和TC已經達標者控製其non-HDL-C和apoB水平在冠心病的防治中有重要意義。
목적：탐토혈청비고밀도지단백담고순이급재지단백B수평대관심병적림상응용개치。방법검측118례관심병(CHD)환자혈청삼선감유(TG)、총담고순(TC)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、재지단백A1(apoAl)화재지단백B(apoB)수평，병계산출비고밀도지단백담고순(non-HDL-C)급apoB/apoA1비치，분석각혈지지표여관심병적관계。결과 CHD환자혈청TG、non-HDL-C화apoB/apoA1비치균고우대조조(P<0.01)，HDL-C화apo Al수평균저우대조조（P<0.01)，차이유통계학의의。 HDL-C화apoA1적진단령민도명현고우TC화LDL-C，이non-HDL-C、apoB이급apoB/apoA1적특이도균교고。결론혈청non-HDL-C급apoB/apoA1비치적승고여심혈관사건발생위험성명현정상관，기예경개치고우전통지표LDL-C화TC，여관상동맥죽양경화병변관계밀절，우기대우LDL-C화TC이경체표자공제기non-HDL-C화apoB수평재관심병적방치중유중요의의。
Objective To investigate the clinical value of non-high-density lipoprotein cholesterol (non-HDL-C) and apolipoprotein B (apoB) in patients with coronary heart disease (CHD). Methods The concentrations of serum triglyceride (TG),to-tal cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (apoA1) and apoB in 118 patients with CHD were detected. Non-HDL-C levels and apoB/apoA1 ratios were calculated. All the results were analyzed with statistical methods. Results The concentrations of serum TG, non-HDL-C and the ratio of apoB/apoA1 in patients with CHD were significantly higher than those of healthy people(P<0.01), while HDL-C and apoA1 were lower(P<0.01). Serum HDL-C and apoA1 have higher diagnostic sensitivity in CHD than serum TC and LDL-C, while serum non-HDL-C, apoB and apoB/apoA1 had higher specificity. Conclusions Serum non-HDL-C and apoB/apoA1 have positive correlation with CHD and their early warning value are better than serum LDL-C and TC. In patients with normal serum LDL-C and TC, controlling their serum non-HDL-C and apoB will have more significance in prevention of CHD.
