CAJ | 학술논문

以3-羟基苯硼酸和取代含溴吡啶为原料，经Suzuki偶联和亲核取代两步反应合成了24个未见报道的含苯基吡啶基团的肟醚乙酸酯类化合物，其结构均通过1 H NMR、ESI-MS和IR确证。初步生物活性测定结果表明，大部分目标化合物具有一定的抑菌活性，其中化合物5i、5r、5t在50 mg/L下对黄瓜霜霉病菌的抑制率达到80％。说明此类化合物具有作为杀菌剂先导进行进一步结构优化的潜力。
이3-간기분붕산화취대함추필정위원료，경Suzuki우련화친핵취대량보반응합성료24개미견보도적함분기필정기단적우미을산지류화합물，기결구균통과1 H NMR、ESI-MS화IR학증。초보생물활성측정결과표명，대부분목표화합물구유일정적억균활성，기중화합물5i、5r、5t재50 mg/L하대황과상매병균적억제솔체도80％。설명차류화합물구유작위살균제선도진행진일보결구우화적잠력。
Twenty four novel methoximinoacetate compounds containing phenylpyridine moieties were synthesized from ( 3-hydroxyphenyl ) boric acid and substituted bromopyridines via Suzuki cross-coupling reaction and nucleophilic substitution. The structures of all compounds were confirmed by 1 H NMR, ESI-MS and IR. Bioactivity tests showed that most of the compounds have moderate to good fungicidal activity and compounds 5i, 5r and 5t exhibited more than 80% inhibition against Pseudoperonospora cubensis at 50 mg/L, which means that the title compounds are potential as the fungicidal lead compounds.