CAJ | 학술논문

喹诺酮类药物以抗菌活性强、抗菌谱广、疗效确切等优点被广泛应用于临床，一些研究结果表明金属离子对喹诺酮类药物的活性有一定的影响。本文概述了喹诺酮类药物的发展及作用机制，总结了金属离子对喹诺酮类的作用及喹诺酮类药物金属配合物的活性，最后展望了喹诺酮类药物今后的发展。
규낙동류약물이항균활성강、항균보엄、료효학절등우점피엄범응용우림상，일사연구결과표명금속리자대규낙동류약물적활성유일정적영향。본문개술료규낙동류약물적발전급작용궤제，총결료금속리자대규낙동류적작용급규낙동류약물금속배합물적활성，최후전망료규낙동류약물금후적발전。
Quinolone are widely used clinically because of its antibacterial activity, widely spectrum antimicrobial, curative ef-fect, etc.Some studies show that the metal ions affect the activity of quinolone.This paper outlines the development and action mecha-nism of quinolone. Summarizes the role of metal ions on metal quinolone and the biological activity of quinolone complexes. Finally, prospects of the development of quinolone.