CAJ | 학술논문

目的：探讨原发于前列腺弥漫大B细胞型非霍奇金淋巴瘤的临床特点、诊断及治疗。方法报道2例原发于前列腺弥漫大B细胞型非霍奇金淋巴瘤患者的临床表现及特点、诊断及治疗方案，并结合文献进行讨论。结果原发于前列腺弥漫大B细胞型非霍奇金淋巴瘤临床表现常有血尿、尿频尿急、排尿困难及出血倾向。2例患者行经直肠彩超引导下前列腺穿刺活检术，病理及免疫组织化学结果均提示为前列腺弥漫大B细胞型非霍奇金淋巴瘤。1例患者给予R-CHOP（利妥昔单抗、环磷酰胺、阿霉素、长春新碱、泼尼松）方案化疗，至今仍在随访中；还有1例患者出院后失访。结论原发于前列腺弥漫大B细胞型非霍奇金淋巴瘤临床罕见，前列腺穿刺活检可以明确诊断，化疗为主要治疗手段，预后受多种因素影响。
목적：탐토원발우전렬선미만대B세포형비곽기금림파류적림상특점、진단급치료。방법보도2례원발우전렬선미만대B세포형비곽기금림파류환자적림상표현급특점、진단급치료방안，병결합문헌진행토론。결과원발우전렬선미만대B세포형비곽기금림파류림상표현상유혈뇨、뇨빈뇨급、배뇨곤난급출혈경향。2례환자행경직장채초인도하전렬선천자활검술，병리급면역조직화학결과균제시위전렬선미만대B세포형비곽기금림파류。1례환자급여R-CHOP（리타석단항、배린선알、아매소、장춘신감、발니송）방안화료，지금잉재수방중；환유1례환자출원후실방。결론원발우전렬선미만대B세포형비곽기금림파류림상한견，전렬선천자활검가이명학진단，화료위주요치료수단，예후수다충인소영향。
Objective To explore the clinical characteristics, diagnosis and treatment of primary diffuse large B-cell non-Hodgkin’s lymphoma of the prostate. Methods Two cases of primary diffuse large B-cell non-Hodgkin’s lymphoma of the prostate were studied by analyzing the clinical manifestations and characteristics, diagnosis, treatment and review of the literature. Results The clinical manifestations of primary diffuse large B-cell non-Hodgkin’s lymphoma of the prostate was hematuria, urinary frequency and urgency, dysuria and bleeding tendency. 2 cases were underwent transrectal prostate biopsy, the pathologic and immunohistochemical results showed that were diffuse large B-cell non-Hodgkin’s lymphoma, 1 patient received R-CHOP chemotherapy and still under follow-up, 1 patient failed to follow-up after discharge. Conclusion Primary diffuse large B-cell non-Hodgkin’s lymphoma of the prostate is rare, transrectal prostate biopsy can confirm the diagnosis, chemotherapy is the major treatment, prognosis is influenced by various factors.