中国医药
中國醫藥
중국의약
CHINA MEDICINE
2014年
8期
1120-1124
,共5页
慢性阻塞性肺疾病%盐酸氨溴索%剂量%老年患者%急性加重期
慢性阻塞性肺疾病%鹽痠氨溴索%劑量%老年患者%急性加重期
만성조새성폐질병%염산안추색%제량%노년환자%급성가중기
Chronic obstructive pulmonary disease%Ambroxol%Dose%Elderly patients%Acute exacerbation
目的 研究不同剂量盐酸氨溴索治疗慢性阻塞性肺疾病急性加重期(AECOPD)老年患者的疗效.方法 选择在温岭市康复医院内科住院的AECOPD老年患者104例,根据住院顺序随机分为大剂量组和小剂量组,各52例.2组患者均接受吸氧、解痉、抗感染等常规治疗,大剂量组患者在此基础上静脉滴注盐酸氨溴索120 mg/d,小剂量组患者静脉滴注盐酸氨溴索60 mg/d.连续治疗1周后,观察2组患者的临床表现、血气等指标的改善情况.结果 大剂量组的总有效率为90.4％ (47/52),小剂量组的总有效率71.2％ (37/52),组间差异有统计学意义(P＜0.05).治疗后2组患者的氧分压和二氧化碳分压相比较,大剂量组指标明显优于小剂量组[(65.2±2.7) mmHg(1 mmHg=0.133 kPa)比(60.9±2.2) mmHg,(46.2±3.0) mmHg比(50.1 ±2.7)mmHg],差值差异有统计学意义[(11.7±1.9) mmHg比(10.5±1.6) mmHg,(12.57±0.22) mmHg比(12.15 ±2.67)mmHg] (P ＜0.05).结论 大剂量盐酸氨溴索的临床疗效显著,可明显改善患者的症状.
目的 研究不同劑量鹽痠氨溴索治療慢性阻塞性肺疾病急性加重期(AECOPD)老年患者的療效.方法 選擇在溫嶺市康複醫院內科住院的AECOPD老年患者104例,根據住院順序隨機分為大劑量組和小劑量組,各52例.2組患者均接受吸氧、解痙、抗感染等常規治療,大劑量組患者在此基礎上靜脈滴註鹽痠氨溴索120 mg/d,小劑量組患者靜脈滴註鹽痠氨溴索60 mg/d.連續治療1週後,觀察2組患者的臨床錶現、血氣等指標的改善情況.結果 大劑量組的總有效率為90.4％ (47/52),小劑量組的總有效率71.2％ (37/52),組間差異有統計學意義(P＜0.05).治療後2組患者的氧分壓和二氧化碳分壓相比較,大劑量組指標明顯優于小劑量組[(65.2±2.7) mmHg(1 mmHg=0.133 kPa)比(60.9±2.2) mmHg,(46.2±3.0) mmHg比(50.1 ±2.7)mmHg],差值差異有統計學意義[(11.7±1.9) mmHg比(10.5±1.6) mmHg,(12.57±0.22) mmHg比(12.15 ±2.67)mmHg] (P ＜0.05).結論 大劑量鹽痠氨溴索的臨床療效顯著,可明顯改善患者的癥狀.
목적 연구불동제량염산안추색치료만성조새성폐질병급성가중기(AECOPD)노년환자적료효.방법 선택재온령시강복의원내과주원적AECOPD노년환자104례,근거주원순서수궤분위대제량조화소제량조,각52례.2조환자균접수흡양、해경、항감염등상규치료,대제량조환자재차기출상정맥적주염산안추색120 mg/d,소제량조환자정맥적주염산안추색60 mg/d.련속치료1주후,관찰2조환자적림상표현、혈기등지표적개선정황.결과 대제량조적총유효솔위90.4％ (47/52),소제량조적총유효솔71.2％ (37/52),조간차이유통계학의의(P＜0.05).치료후2조환자적양분압화이양화탄분압상비교,대제량조지표명현우우소제량조[(65.2±2.7) mmHg(1 mmHg=0.133 kPa)비(60.9±2.2) mmHg,(46.2±3.0) mmHg비(50.1 ±2.7)mmHg],차치차이유통계학의의[(11.7±1.9) mmHg비(10.5±1.6) mmHg,(12.57±0.22) mmHg비(12.15 ±2.67)mmHg] (P ＜0.05).결론 대제량염산안추색적림상료효현저,가명현개선환자적증상.
Objective To study the different doses of ambroxol treating acute exacerbation of chronic obstructive pulmonary disease in elderly patients.Methods Totally 104 acute exacerbation chronic obstructive pulmonary disease patients were randomly divided into high-dose group and small-dose group;two groups were given oxygen inhalation,spasmolysis,antibiotics and other conventional treatments ; control group was given small dose ambroxol intravenous injection;the high-dose group had the conventional treatment.After 1 week of continuous treatment,the improvement of clinical symptoms and blood gas indexes was observed.Results The effective rate in high-dose group was 90.4％ (47/52) ; the total effective rate of small dose group was 71.2％ (37/52) ; the difference was statistically significant (P ＜ 0.05).After treatment,the partial pressure of oxygen and dioxide in high-dose group were obviously better than those in small dose group [(65.2 ± 2.7) mmHg vs (60.9 ± 2.2) mmHg,(46.2 ± 3.0) mmHg vs (50.14 ± 2.68) mmHg; (11.7 ± 1.9) mmHg vs (10.5 ± 1.6) mmHg,(12.57 ± 0.22)mmHg vs (12.15 ±2.67)mmHg] (P＜0.05).Conclusion The large dose of ambroxol can significantly improve the symptoms of acute exacerbation of chronic obstructive pulmonary disease in elderly patients.
