实用临床医学
實用臨床醫學
실용림상의학
Practical Clinical Medicine
2014年
6期
86-88,90
,共4页
新生儿窒息%心肌损伤%糖原磷酸化酶同工酶脑型%肌营养素-1
新生兒窒息%心肌損傷%糖原燐痠化酶同工酶腦型%肌營養素-1
신생인질식%심기손상%당원린산화매동공매뇌형%기영양소-1
neonatal asphyxia%myocardial injury%glycogen phosphorylase isoenzyme BB%cardiotrophin-1
目的：探讨合并心肌损伤的窒息新生儿血浆心肌营养素-1(cardio trophin-1，CT-1)以及糖原磷酸化酶同工酶脑型（glycogen phosphorylase isoenzyme BB，GPBB）的变化及其临床意义。方法选择72例合并心肌损伤窒息新生儿为试验组[其中轻度窒息39例（轻度窒息组），重度窒息33例（重度窒息组）]，32例健康新生儿为对照组，采用酶联免疫吸附法（ELISA)测定血浆GPBB、CT-1水平，并分析血浆GPBB、CT-1水平与窒息程度的关系。结果试验组血浆GPBB、CT-1水平均明显高于对照组（均P＜O.05）；重度窒息组血浆GPBB、CT-1明显高于轻度窒息组（均P＜O.05)；血浆GPBB水平、CT-1与窒息程度均呈负相关（r＝-0.519、r＝-0.527，P＜O.05）；血浆GPBB水平与CT-1水平呈正相关关系（r＝0.547，P＜O.05）。结论合并心肌损伤的窒息新生儿血浆CT-1以及GPBB水平明显升高，且与窒息程度密切相关，窒息程度越重其水平越高，提示与新生儿窒息心肌损伤有密切关系；测定血浆CT-1以及GPBB水平有助于判断新生儿窒息合并心肌损伤的程度。
目的：探討閤併心肌損傷的窒息新生兒血漿心肌營養素-1(cardio trophin-1，CT-1)以及糖原燐痠化酶同工酶腦型（glycogen phosphorylase isoenzyme BB，GPBB）的變化及其臨床意義。方法選擇72例閤併心肌損傷窒息新生兒為試驗組[其中輕度窒息39例（輕度窒息組），重度窒息33例（重度窒息組）]，32例健康新生兒為對照組，採用酶聯免疫吸附法（ELISA)測定血漿GPBB、CT-1水平，併分析血漿GPBB、CT-1水平與窒息程度的關繫。結果試驗組血漿GPBB、CT-1水平均明顯高于對照組（均P＜O.05）；重度窒息組血漿GPBB、CT-1明顯高于輕度窒息組（均P＜O.05)；血漿GPBB水平、CT-1與窒息程度均呈負相關（r＝-0.519、r＝-0.527，P＜O.05）；血漿GPBB水平與CT-1水平呈正相關關繫（r＝0.547，P＜O.05）。結論閤併心肌損傷的窒息新生兒血漿CT-1以及GPBB水平明顯升高，且與窒息程度密切相關，窒息程度越重其水平越高，提示與新生兒窒息心肌損傷有密切關繫；測定血漿CT-1以及GPBB水平有助于判斷新生兒窒息閤併心肌損傷的程度。
목적：탐토합병심기손상적질식신생인혈장심기영양소-1(cardio trophin-1，CT-1)이급당원린산화매동공매뇌형（glycogen phosphorylase isoenzyme BB，GPBB）적변화급기림상의의。방법선택72례합병심기손상질식신생인위시험조[기중경도질식39례（경도질식조），중도질식33례（중도질식조）]，32례건강신생인위대조조，채용매련면역흡부법（ELISA)측정혈장GPBB、CT-1수평，병분석혈장GPBB、CT-1수평여질식정도적관계。결과시험조혈장GPBB、CT-1수평균명현고우대조조（균P＜O.05）；중도질식조혈장GPBB、CT-1명현고우경도질식조（균P＜O.05)；혈장GPBB수평、CT-1여질식정도균정부상관（r＝-0.519、r＝-0.527，P＜O.05）；혈장GPBB수평여CT-1수평정정상관관계（r＝0.547，P＜O.05）。결론합병심기손상적질식신생인혈장CT-1이급GPBB수평명현승고，차여질식정도밀절상관，질식정도월중기수평월고，제시여신생인질식심기손상유밀절관계；측정혈장CT-1이급GPBB수평유조우판단신생인질식합병심기손상적정도。
Objective To observe the changes in plasma cardiotrophin-1 (CT-1)and glycogen phosphorylase isoenzyme BB (GPBB) and their clinical significance in asphyxiated newborn infants with myocardial injury. Methods The levels of plasma CT-1 and GPBB were detected by ELISA in 72 asphyxiated newborn infants with myocardial injury (experimental group) and 32 healthy newborns (control group).In addition, infants in experimental group were further divided into mild asphyxia group (n=39)and severe asphyxia group (n=33). The relationships of asphyxia degree to CT-1 and GPBB levels were analyzed. Results Compared with control group, levels of GPBB and CT-1 significantly decreased in experimental group(P<0.05).Compared with mild asphyxia group,levels of GPBB and CT-1 significantly increased in severe asphyxia group. The levels of plasma GPBB and CT-1 were negatively correlated with the degree of asphyxia (r=-0.519 and r=-0.527, respectively, P<0.05). Moreover, GPBB levels were positively correlated with CT-1 levels (r=0.547, P<0.05). Conclusion The levels of plasma GPBB and CT-1 increase obviously and are negatively correlated with the degree of asphyxia in asphyxiated newborn infants with myocardial injury, suggesting that there is a relationship between neonatal asphyxia and myocardial injury. The detection of plasma GPBB and CT-1 levels can help to determine the degree of neonatal asphyxia with myocardial injury.
