CAJ | 학술논문

目的：探讨ω-3多不饱和脂肪酸对体外循环下心脏直视手术围术期患者白细胞介素-6（IL-6）、围术期出血量的影响。方法收集2013年1月至12月收治的需要行心脏手术的患者，分为治疗组及对照组，各15例，治疗组加用ω-3多不饱和脂肪酸（尤文）：0.2g/（kg?d），并分别于Tl：手术开始前；T2：升主动脉阻断后1h；T3：升主动脉开放后30min；T4：升主动脉开放后1h；T5：体外循环结束后2h；T6：手术后6h；T7：手术后12h；T8：手术后24h；T9：手术后48h；T10：手术后72h。收集患者血清，用ELISA法检测IL-6水平。结果自手术开始，IL-6水平明显升高，治疗组IL-6水平明显低于对照组，差异有统计学意义（P<0.05）。两组患者围术期出血量及输血量差异无统计学意义（P>0.05）。结论鱼油能减轻心脏手术围术期患者炎性反应，不会引起围术期出血量增多，可安全用于心脏手术围术期。
목적：탐토ω-3다불포화지방산대체외순배하심장직시수술위술기환자백세포개소-6（IL-6）、위술기출혈량적영향。방법수집2013년1월지12월수치적수요행심장수술적환자，분위치료조급대조조，각15례，치료조가용ω-3다불포화지방산（우문）：0.2g/（kg?d），병분별우Tl：수술개시전；T2：승주동맥조단후1h；T3：승주동맥개방후30min；T4：승주동맥개방후1h；T5：체외순배결속후2h；T6：수술후6h；T7：수술후12h；T8：수술후24h；T9：수술후48h；T10：수술후72h。수집환자혈청，용ELISA법검측IL-6수평。결과자수술개시，IL-6수평명현승고，치료조IL-6수평명현저우대조조，차이유통계학의의（P<0.05）。량조환자위술기출혈량급수혈량차이무통계학의의（P>0.05）。결론어유능감경심장수술위술기환자염성반응，불회인기위술기출혈량증다，가안전용우심장수술위술기。
Objective To evaluate the impact ofω-3 fish oil fatty emulsion on IL-6 and hemostasis in patients with operation of cardiopulmonary bypass cardiac surgical procedures. Methods A total of 30 patients with cardiac disease receiving cardiopulmonary bypass were randomly assigned to two groups: trial group(n=15)and control group(n=15). The patients in trial group was administeredω-3 fish oil fatty emulsion 0.2g/(kg?d). At the time point of before incision(T1),1 hour after aortic clamping time (T2),30 minutes after aortic opening time(T3),1 hour after aortic opening time(T4),2 hours at the end of cardiopulmonary bypass(T5),6 hours(T6),12 hours(T7),24 hours(T8),48 hours(T9)and 72 hours(T10)post-operation,plasma concentrations of IL-6 in both groups were measured. Results The plasma IL-6 concentration increased significantly at T2 and reached its peak at T5 in the trial group and control group,and then declined at T6. At T4、T8、T7,the concentration was significantly lower in the trial group than the control group(P<0.01).whereas,there was no significant differences in amount of bleeding and transfusion volume(P>0.05). Conclusions ω-3 fish oil fatty emulsion can significantly reduce the concentration of IL-6 during operative period in patients receiving cardiac surgery with cardiopulmonary bypass.