浙江临床医学
浙江臨床醫學
절강림상의학
ZHEJIANG CLINICAL MEDICAL JOURNAL
2014年
7期
1024-1026,1032
,共4页
张庆雷%朱斌%杨献峰%沈祎%张冰
張慶雷%硃斌%楊獻峰%瀋祎%張冰
장경뢰%주빈%양헌봉%침의%장빙
脂肪肝%磁共振氢质子波谱成像%定量分析%CT
脂肪肝%磁共振氫質子波譜成像%定量分析%CT
지방간%자공진경질자파보성상%정량분석%CT
Fatty liver%Proton magnetic resonance spectroscopy%Quantitative analysis%CT
目的:探讨3.0T磁共振HMR波谱(HMRS)成像技术在定量分析评估脂肪肝治疗效果中的临床应用。方法收集弥漫性脂肪肝患者39例,在干预治疗前及治疗后9个月,空腹行CT上腹部平扫,肝脏超声,MR双回波序列DUAL,常规横断位T2WI-TSE,T2WI-SPAIR,冠状位Balanced-FFE,及HMRS检查,通过分析计算HMRS图像在特定化学位点上的水峰(4.7ppm)、脂质峰(1.0~1.5ppm)的波峰峰值和波峰下面积,进行准确定量肝脏内脂质含量(intra hepatic content of lipid, IHCL),根据超声结果及CT的L/S值(肝脾CT值的比值)评估脂肪肝程度的标准,探讨HMRS在定量分析弥漫性脂肪肝疗效中的作用。结果超声及CT检查成功率100%,获得可用数据,HMRS检查成功率为97%,38例取得明确磁共振波谱成像,1例波谱成像基线不稳,杂峰较多,影响评价而被排除。结论超声以及CT检查均可有效检测脂肪肝严重程度,3.0T HMRS可更精确的定量分析脂肪肝的临床疗效。
目的:探討3.0T磁共振HMR波譜(HMRS)成像技術在定量分析評估脂肪肝治療效果中的臨床應用。方法收集瀰漫性脂肪肝患者39例,在榦預治療前及治療後9箇月,空腹行CT上腹部平掃,肝髒超聲,MR雙迴波序列DUAL,常規橫斷位T2WI-TSE,T2WI-SPAIR,冠狀位Balanced-FFE,及HMRS檢查,通過分析計算HMRS圖像在特定化學位點上的水峰(4.7ppm)、脂質峰(1.0~1.5ppm)的波峰峰值和波峰下麵積,進行準確定量肝髒內脂質含量(intra hepatic content of lipid, IHCL),根據超聲結果及CT的L/S值(肝脾CT值的比值)評估脂肪肝程度的標準,探討HMRS在定量分析瀰漫性脂肪肝療效中的作用。結果超聲及CT檢查成功率100%,穫得可用數據,HMRS檢查成功率為97%,38例取得明確磁共振波譜成像,1例波譜成像基線不穩,雜峰較多,影響評價而被排除。結論超聲以及CT檢查均可有效檢測脂肪肝嚴重程度,3.0T HMRS可更精確的定量分析脂肪肝的臨床療效。
목적:탐토3.0T자공진HMR파보(HMRS)성상기술재정량분석평고지방간치료효과중적림상응용。방법수집미만성지방간환자39례,재간예치료전급치료후9개월,공복행CT상복부평소,간장초성,MR쌍회파서렬DUAL,상규횡단위T2WI-TSE,T2WI-SPAIR,관상위Balanced-FFE,급HMRS검사,통과분석계산HMRS도상재특정화학위점상적수봉(4.7ppm)、지질봉(1.0~1.5ppm)적파봉봉치화파봉하면적,진행준학정량간장내지질함량(intra hepatic content of lipid, IHCL),근거초성결과급CT적L/S치(간비CT치적비치)평고지방간정도적표준,탐토HMRS재정량분석미만성지방간료효중적작용。결과초성급CT검사성공솔100%,획득가용수거,HMRS검사성공솔위97%,38례취득명학자공진파보성상,1례파보성상기선불은,잡봉교다,영향평개이피배제。결론초성이급CT검사균가유효검측지방간엄중정도,3.0T HMRS가경정학적정량분석지방간적림상료효。
Objective To investigate the clinical treatment effect of proton magnetic resonance spectroscopy(1 H-MRS) imaging,by which to quantitatively analyze liver fat content for therapeutic evaluation of fatty liver at 3.0 T MRI. Methods 39 patients on an empty stomach with diffused fatty liver underwent CT,B-Ultrasound and MR dual-echo chemical shift gradient-echo imaging simultaneously,T2WI-TSE,T2WI-SPAIR,Balanced-FFE and HMRS. The values of water peak(4.7ppm),lipid peak (1.0-1.5ppm)the area under water peak(Aw)and lipid peak(AL)were measured,accurate quantitative IHCL. According to the B-ultrasound and L/S,quantitatively analyzing liver fat content for therapeutic evaluation of fatty liver. Results The success rate was 100%in B-Ultrasound and CT. The success rate was 97%in HMRS,the data of 38 patients were available . Conclusion B-Ultrasound and CT are effective Methods. 3.0T HMRS is an more precise method in clinical application in quantitative diagnosis the therapeutic effect of fatty liver.