CAJ | 학술논문

目的：评价莫沙必利与奥美拉唑联合用药治疗胃食管反流病（GERD）的疗效与不良反应。方法：将80例GERD患者随机分为治疗组和对照组（各40例）。治疗组服用奥美拉唑（20 mg，bid）+莫沙必利（5 mg，tid），对照组服用莫沙必利（5 mg，tid），疗程均为8周。治疗结束后比较两组患者的常见症状缓解率以及药物的不良反应，并通过胃镜观察比较有效率。结果：治疗8周后，治疗组患者烧心、反酸、反流、胸痛等症状的平均缓解率高于对照组患者（85.7％vs.63.3％，P＜0.05），镜下有效率高于对照组患者（77.5％vs.52.5％，P＜0.05），差异均有统计学意义。治疗过程中，患者耐受均良好，无严重不良反应。结论：莫沙必利联合奥美拉唑治疗GERD可达到较高的症状缓解率和镜下有效率，临床疗效、安全性均较好。
목적：평개막사필리여오미랍서연합용약치료위식관반류병（GERD）적료효여불량반응。방법：장80례GERD환자수궤분위치료조화대조조（각40례）。치료조복용오미랍서（20 mg，bid）+막사필리（5 mg，tid），대조조복용막사필리（5 mg，tid），료정균위8주。치료결속후비교량조환자적상견증상완해솔이급약물적불량반응，병통과위경관찰비교유효솔。결과：치료8주후，치료조환자소심、반산、반류、흉통등증상적평균완해솔고우대조조환자（85.7％vs.63.3％，P＜0.05），경하유효솔고우대조조환자（77.5％vs.52.5％，P＜0.05），차이균유통계학의의。치료과정중，환자내수균량호，무엄중불량반응。결론：막사필리연합오미랍서치료GERD가체도교고적증상완해솔화경하유효솔，림상료효、안전성균교호。
OBJECTIVE:To evaluate the efficacy and safety of mosapride combined with omeprazole in treatment of gastro-esophageal reflux disease. METHODS:80 patients with gastroesophageal reflux disease were randomly divided into a treatment group(n=40)and control group(n=40). Treatment group was given omeprazole(20 mg,bid)plus mosapride(5 mg,tid)while the control group was given mosapride(5 mg,tid)for 8 weeks. After treatment completion,the rate of patients showing relief of common symptoms and the adverse drug reactions were compared between the two groups;and the effective rate was evaluated by gastroscopy. RESULTS:After 8-week treatment,the patients in the treatment group showed high rate of relief of common symp-toms including heartburn,sour regurgitation,chest pain and other symptoms than in the control group on average (85.7% vs. 63.3%,P<0.05),and the effective rate evaluated by gastroscopy was also higher than in the control group(77.5% vs. 52.5%,P<0.05). During treatment,all of the patients were well tolerated,with no serious adverse reactions noted. CONCLUSIONS:Mo-sapride combined with omeprazole resulted in high rate of symptom relief and high effective rate gastroscopically with good clinical efficacy and safety in patients with gastroesophageal reflux disease.