新医学
新醫學
신의학
NEW CHINESE MEDICINE
2014年
7期
464-467
,共4页
计算法%肾小球滤过率%血清肌酐%胱抑素C%临床因素
計算法%腎小毬濾過率%血清肌酐%胱抑素C%臨床因素
계산법%신소구려과솔%혈청기항%광억소C%림상인소
Calculation method%GFR%SCr%SCy-C%Clinical factor
目的：探讨全国肾小球滤过率（GFR）课题协作组改良简化MDRD方程计算所得估算GFR （eGFR）的影响因素。方法选择70例慢性肾衰竭（CRF）患者及67名健康人，分别检测血清肌酐、胱抑素C、血尿素氮、血尿酸、血钾、血钠、血氯、血钙、血清白蛋白、血红蛋白，并测定心率、平均肱动脉压、BMI、体表面积、尿比密、24 h尿蛋白定量，记录受测者性别、年龄，用改良简化MDRD方程计算eGFR。对各临床指标与eGFR的关系行直线相关分析及多元回归分析。结果正常人的eGFR分别与血清肌酐、胱抑素和年龄呈负相关（P＜0.05或0.01）。CRF患者eGFR仅与血清肌酐、胱抑素C有关（P均＜0.01）。慢性肾小球肾炎引致CRF患者及其他病因引致CRF患者的eGFR均与血清肌酐、胱抑素呈负相关（P均＜0.01）。结论对于慢性肾衰竭患者及健康人，血清肌酐及胱抑素C均为影响eGFR的重要因素。
目的：探討全國腎小毬濾過率（GFR）課題協作組改良簡化MDRD方程計算所得估算GFR （eGFR）的影響因素。方法選擇70例慢性腎衰竭（CRF）患者及67名健康人，分彆檢測血清肌酐、胱抑素C、血尿素氮、血尿痠、血鉀、血鈉、血氯、血鈣、血清白蛋白、血紅蛋白，併測定心率、平均肱動脈壓、BMI、體錶麵積、尿比密、24 h尿蛋白定量，記錄受測者性彆、年齡，用改良簡化MDRD方程計算eGFR。對各臨床指標與eGFR的關繫行直線相關分析及多元迴歸分析。結果正常人的eGFR分彆與血清肌酐、胱抑素和年齡呈負相關（P＜0.05或0.01）。CRF患者eGFR僅與血清肌酐、胱抑素C有關（P均＜0.01）。慢性腎小毬腎炎引緻CRF患者及其他病因引緻CRF患者的eGFR均與血清肌酐、胱抑素呈負相關（P均＜0.01）。結論對于慢性腎衰竭患者及健康人，血清肌酐及胱抑素C均為影響eGFR的重要因素。
목적：탐토전국신소구려과솔（GFR）과제협작조개량간화MDRD방정계산소득고산GFR （eGFR）적영향인소。방법선택70례만성신쇠갈（CRF）환자급67명건강인，분별검측혈청기항、광억소C、혈뇨소담、혈뇨산、혈갑、혈납、혈록、혈개、혈청백단백、혈홍단백，병측정심솔、평균굉동맥압、BMI、체표면적、뇨비밀、24 h뇨단백정량，기록수측자성별、년령，용개량간화MDRD방정계산eGFR。대각림상지표여eGFR적관계행직선상관분석급다원회귀분석。결과정상인적eGFR분별여혈청기항、광억소화년령정부상관（P＜0.05혹0.01）。CRF환자eGFR부여혈청기항、광억소C유관（P균＜0.01）。만성신소구신염인치CRF환자급기타병인인치CRF환자적eGFR균여혈청기항、광억소정부상관（P균＜0.01）。결론대우만성신쇠갈환자급건강인，혈청기항급광억소C균위영향eGFR적중요인소。
Objective To investigate the influential factors of GRF (eGFR)calculated by the modi-fied Modification of Diet in Renal Disease (MDRD)equation. Methods Seventy patients with chronic renal failure (CRF)and sixty-seven healthy subjects were recruited in this study. Serum Cr,SCy-C,BUN,UA,po-tassium,sodium,chlorine,calcium,SA1 b and hemoglobin were detected. Heart rate,mean brachial blood pressure,body mass index,body surface area,urine specific gravity,24 h urine protein quantization were measured. Gender and age of all participants were recorded. eGFR was calculated by modified MDRD equa-tion. Linear correlation and multivariate regression analysis between eGFR and clinical factors were analyzed.Results For healthy controls,eGFR was negatively correlated with SCr,SCy-C and age (P<0.05 or P<0.01). For CRF patients,eGFR was negatively associated with SCr and SCy-C (both P<0.01)For CRF pa-tients induced by CGN and alternative causes,eGFR was negatively correlated with SCr and SCy-C (all P<0.01). Conclusion For both CRF and normal subjects,SCr and SCy-C act as pivotal influential factors af-fecting eGFR.
